CIULLA_LIVER FUNCTION & PORPHYRIN FORMATION

Principal pigment in bile that is derived from hemoglobin breakdown

From what system is bilirubin produced

Bilirubin is produced from the breakdown of ____.

Prior to transport to the liver, bilirubin forms a complex with _______.

Upon forming a complex with albumin, bilirubin is (conjugated/unconjugated) and (is/not) water-soluble.

Where is bilirubin conjugated

Product of conjugation of bilirubin and glucuronic acid

Reaction of bilirubin and glucuronic acid is catalyzed by ________.

T/F: Conjugated bilirubin is water-soluble.

Conjugated bilirubin is excreted into what form prior to storage in the gallbladder?

Conjugated bilirubin is stored in the ______.

Pathways of urobilinogen

Once conjugated bilirubin is excreted into bile, and secreted into the duodenum in response to gallbladder stimulation, it is further reduced by anaerobic bacteria in the intestine to _______.

Some bilirubin is oxidized by anaerobic bacteria for excretion in the stool in the form of ______.

an orange-brown pigment that gives stool its characteristic color.

a yellow discoloration that occurs when the bilirubin concentration in the blood rises and the bilirubin is deposited in the skin and sclera of the eyes.

what concentration of bilirubin will jaundice be considered?

Elevated bilirubin deposits in brain tissue of infants, affecting the central nervous system and resulting in mental retardation.

Bile is secreted by _____.

Bile is stored in the _______.

Composition of bile salts

the primary site in the body for synthesis of waste products

the primary site in the body for d conversion of drugs to metabolites for excretion in urine or stool

type of jaundice which occurs when there is excessive erythrocyte destruction, as seen in hemolytic anemias, spherocytosis, toxic conditions, hemolytic disease of the newborn caused by Rh or ABO incompatibility