[2S] UNIT 9.2 Uric Acid Determination
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One of the NPNs present in the bloodstream
Uric Acid
Organ in trouble when there is elevation of NPNs in the bloodstream
Kidneys
Only NPN that tells that the liver is in trouble if it is elevated in the bloodstream
Ammonia
Toxic byproduct that needs to be converted to urea for detoxification
Ammonia
Other NPNs circulating in the plasma Not considered as waste product
Amino acids
Other NPNs circulating in the plasma ● Waste products ● Body needs to get rid of
Urea, Uric acid, Creatinine, Ammonia
End product of purine catabolism
Uric Acid
End product of protein catabolism
Urea
T/F: Urea is higher compared to creatinine
T
Precursor of uric acid
Xanthine
Where is uric acid produced?
Liver
Xanthine is acted upon by what enzyme and to be converted to?
○ Acted upon by Xanthine oxidase ○ To be converted to uric acid
It is a waste product
Uric Acid
Main product of the catabolism of exogenous (dietary) and endogenous purine nucleosides (Adenine and Guanine)
Uric Acid
T/F: Most uric acids are reabsorbed and 1% is excreted
T
T/F: Decrease in serum uric acid is common
F; uncommon
T/F: Although uric acid measurement may assess kidney function, uric acid is not as reliable as that of urea and creatinine.
T
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS 1st organ
Liver
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS ■ Cells that make up the lobules ■ It is where uric acid is produced
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS Functional unit of the liver
Lobules
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS Very vascular organ riched with blood vessels
Liver
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS In the liver, ______ synthesize the uric acid
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS travels in the bloodstream in order for them to be disposed properly
Hepatocytes
HOW IT TRAVELS FROM HEPATOCYTE TO KIDNEYS Urinary bladder → urethra (vary in size)
Inner Medulla