Pathophysiology lecture 4
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What are key components of innate immune system
-Physical barriers -Sentinal cells -circulating phagocytes and granules -Blood proteins like complement -cytokines
What are physical barriers component composed of
-skin -Gi tract -respiroty tract -genitourinary tract
What are the epithelial barriers of composed of
physical and anti microbial -physcial composed of tight junctions, keratin layers (physcial barriers),and mucose
What are antimicrobial components composed of and are aprt of what?
Apart of epithelial barriers composed of Defensin: peptides work by inserting themselve in pathogen creating pores and Cathelicidins: same as defensins but also play role in modulaitng the immune repsonse.
When are defensin and cathelcidins made?
either constitutive:baisclly these are made all the time OR Enhanced production: Toll like receptors recognize germs and TRIGGER production.