proteins II
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it evaluates degree of intravascular hemolysis (HTR and HDN) a, hemopexin b. GC globulin c. Haptoglobulin d. ceruloplasmin
haptoglobulin • a2 glycoprotein • apr • it binds free hemoglobin by its chan • prevents the loss of hgb and its constituent iron into the urine • evaluate degree intravascular hemolysis (HTR and HDN) • slightly decreased after blood transfusion • it is one of the proteins evaluates rheumatic disease
proteins increased in stressful conditions a, hemopexin b. GC globulin c. Haptoglobulin d. ceruloplasmin
haptoglobulin • evaluate degree intravascular hemolysis (HTR and HDN) • slightly decreased after blood transfusion • it is one of the proteins evaluates rheumatic disease • increased: STRESSFUL CONDITIONS, MYOGLOBULINURIA • decreased : INTRAVSCULAR HEMOLYSIS AND HEMOGLOBINURIA
blue color to ptotein a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
Ceruloplasmin • copper binding alpha 2 glycoprotein that has enzymatic activities • synthesized in the liver that has 6-8 atoms attached • blue color to protein • marker for Wilson’s disease
kayser fleisher rings a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
Ceruloplasmin • marker for Wilson’s disease • clinical feature of wilson’s disease • deposition of copper in skin, liver , brain and eye (KAYSER FLEISHER RINGS)
DECREASED: menke’s kinky hair syndrome a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
ceruloplasmin - increased : Inflammation, cancer, pregnancy • decreased: Wilson’s disease , Malnutrition, malabsorption, nephritic disease and Menke’s kinky hair’s syndrome
largest non immunoglobulin protein in plasma a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
alpha 2 - macroglobulin (AMG) - largest non immunoglobulin protein in plasma - found in intravascular spaces - it inhibits proteases : trypsin, pepsin and plasmin - increase in Nephrosis (10x) , diabetes and Liver disease -
it forms complex with prostate specific antigen a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
alpha 2 - macroglobulin (AMG) - it FORMS COMPLEX with prostate specific antigen alpha 1 - antichymotrypsis (a1-X) - BINDS AND ACTIVATES PSA
light chain component of major human leukocyte antigen a. ceruloplasmin b. haptoglobulin c. alpha 2 microglobulin d. beta 2 microglobulin
beta2 - microglobulin - lc of major HLA - found on the surface of all nucleated cells `- present in high concentration of lymphocytes
Synthesized in the plasma cell a. ceruloplasmin b. transferrin c. immunoglobulin d. lipoprotein
immunoglobulins - they are synthesized in the plasma cells
increased : hemochromatosis a. ceruloplasmin b. transferrin c. immunoglobulin d. lipoprotein
transferrin (siderophilin) • increased : HEMOCHROMATOSIS (BRONZE SKIN) , IDA • decreased: Liver disease, MAlnutrition, nephrotic syndrome
major component of beta2 globulin fraction a. ceruloplasmin b. transferrin c. immunoglobulin d. lipoprotein
transferrin (siderophilin) • major component of B2 globulin fraction • negative APR • transports iron to its storage sites • prevent loss of iron through the kidneys
in IDA what is the concentration of transferrin a. increased b, decreased
in IDA transferrin concentration is NORMAL / INCREASED • an elevated plasma level appears as “ paraprotein” - PSEUDOPARAPROTEINEMIA in SEVERE IDA
one of the largest proteins in the blood a. transferrin b. immunoglobulin c. fibrinogen d. lipoprotein
fibrinogen - one of the largest protein in the blood -