18. Instrument and Method Evaluation
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The lowest actual concentration at which the precision of measurement is still LESS than the allowable error
LOQ
What are the 2 categories of systematic errors?
• Proportional systematic error - Constant error
3 terms that describe aspects of the minimum analytical sensitivity of a method
• Limit of blank (LOB) • Limit of detection (LOD) • Limit of quantitation (LOQ)
Lamp, cuvette, calibration changes, picric acid coating cuvette are all examples of what type of error?
Systematic errors
How are proportional systematic errors assessed?
Recovery studies
Compares patient sample results between new method and comparative method
Correlation studies
Errors that result from biases are introduced by what 3 ways?
• Instrumental bias • Method bias • Human bias
4 approaches to analyzing comparison of method data
• Correlation coefficient • T-test statistics • Linear regression statistics • Estimation of Total Error and allowable total error
How are ‘constant errors’ assessed?
Interference studies
Bias is assessed by..?
Correlation studies