Extracellular Matrix

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

Front (Question)

What does ECM consist of?

Back (Answer)

Both fibrillar and non-fibrillar components - proteins and carbohydrates filling spaces between cells

Front (Question)

What are the key functions of ECM?

Back (Answer)

• Provides physical support • Determines the mechanical and physicochemical properties of the tissue • Influences the growth, adhesion and differentiation status of cells

Front (Question)

Which tissue is composed of ECM+component cells?

Back (Answer)

Connective tissue

Front (Question)

Which collagens are components of connective tissue?

Back (Answer)

Types I, II, III (fibrillar) Type IV (basement membrane)

Front (Question)

Which glycoproteins are components of connective tissue?

Back (Answer)

Fibronectin Fibrinogen Laminins (basement membrane)

Front (Question)

Which proteoglycans are components of connective tissue?

Back (Answer)

Aggrecan Versican Decorin Perlecan (basement membrane)

Front (Question)

What are the properties of connective tissue in the form of tendon and skin?

Back (Answer)

Tough but flexible

Front (Question)

What are the properties of connective tissue in the form of bone?

Back (Answer)

Hard and dense

Front (Question)

What are the properties of connective tissue in the form of cartilage?

Back (Answer)

Resilient and shock-absorbing

#10

Front (Question)

How do different types of connective tissue have different properties?

Back (Answer)

Different types and arrangements of oxygen

#11

Front (Question)

List the genetic disorders affecting ECM proteins

Back (Answer)

Osteogenesis imperfecta (OI) Marfan’s syndrome Alport’s syndrome Epidermolysis bulllosa Congenital muscular dystrophy (CMD)

#12

Front (Question)

What is a genetic disorder affecting ECM catabolism?

Back (Answer)

Hurler’s syndrome

#13

Front (Question)

Which ECM component is affected in OI?

Back (Answer)

Type I collagen

#14

Front (Question)

Which ECM component is affected in Marfan’s syndrome?

Back (Answer)

Fibrillin-1

#15

Front (Question)

Which ECM component is affected in Alport’s syndrome?

Back (Answer)

Type IV collagen (α5 chain)

#16

Front (Question)

Which ECM component is affected in Epidermolysis bullosa?

Back (Answer)

Laminin 5 (in all 3 chains)

#17

Front (Question)

Which ECM component is affected in CMD?

Back (Answer)

Laminin 2 (α2 chain)

#18

Front (Question)

Which genetic disorder disrupts the function of L-α-iduronidase?

Back (Answer)

Hurler’s syndrome

#19

Front (Question)

Identify the fibrotic disorders due to excessive ECM deposition?

Back (Answer)

Liver fibrosis - cirrhosis Kidney fibrosis - diabetic nephropathy Lung fibrosis - idiopathic pulmonary fibrosis (IPF)

#20

Front (Question)

What causes osteoarthritis?

Back (Answer)

excessive loss of ECM

#21

Front (Question)

What is a disorder caused by excessive loss of ECM

Back (Answer)

osteoarthritis

#22

Front (Question)

Which group of proteins are most abundant in mammals?

Back (Answer)

Collagens - 25% of total protein mass

#23

Front (Question)

How are collagen fibrils aligned in skin?

Back (Answer)

successive layers nearly at right angles to each other

#24

Front (Question)

How many collagen types are there in humans?

Back (Answer)

28 types