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Aging and senescence

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Total cards: 13•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (13)

#1
Front (Question)

What is senescence?

Back (Answer)

Age dependent decline in vital physiological functions

#2
Front (Question)

What is the disposable soma theory?

Back (Answer)

Natural selection has caused organisms to have sufficient resources/ repair mechanisms to prevent ageing- at least until the organisms have reproduced and cared for their young

#3
Front (Question)

What are the senescence factors?

Back (Answer)

• Metabolism • Reactive oxygen species • DNA damage

#4
Front (Question)

What are factors that increase lifespan?

Back (Answer)

• Dietary restriction • Environmental stress • Signals from the somatic gonad

#5
Front (Question)

What is the reactive oxygen species?

Back (Answer)

O2-

#6
Front (Question)

What causes progeria syndromes?

Back (Answer)

Nuclear lamina mutations

#7
Front (Question)

What causes nestor guillermo?

Back (Answer)

BANF1 mutations- affects the nuclear lamina/ mitosis

#8
Front (Question)

What does diminished insulin signalling in c. elegans and drosophila cause?

Back (Answer)

Increase in lifespan

#9
Front (Question)

How does IGF signalling influence DAF16/ FOXO?

Back (Answer)

Inhibits FOXO

#10
Front (Question)

What does decreased TOR activity cause?

Back (Answer)

Increased lifespan

#11
Front (Question)

What are the genes downstream of FOXO?

Back (Answer)

• Antioxidant genes • Chaperones • Metabolic genes • Antibacterial genes

#12
Front (Question)

What do sirtuins do?

Back (Answer)

Prevent ageing They activate FOXO and the mitochondrial unfolded protein response

#13
Front (Question)

What activated sirtuins?

Back (Answer)

NAD- levels decline with age