Rb
暂无描述。系统推荐的高质量记忆内容，适合每天坚持背诵学习。
卡片预览 (6 张)
what does Rb stand for?
retinoblastoma protein (Rbp)
is Rbp a tumour suppressor or an oncogene?
tumour suppressor
what point of the cell cycle is regulated by Rb?
the restriction point - point in G1 (before S-phase)
what does Rb bind to and what happens to allow cell cycle to continue?
Rb binds and represses E2F transcription factor • Rb recruits histone deacetylases which cause chromosome compaction and repression of transcription in G1 (prevent entry into Sphase) • Mitogens upregulate expression of cyclin D • Cyclin D monophosphorylates/ hypophosphorylates Rb • Rb loses binding to E2F • this causes transcription of cell cycle genes e.g. cyclin E • cyclin E hyperphosphorylates Rb • Rb falls off complex with histone deacytylase • cell cycle gene transcription can occur - S-phase and mitosis can occur
is the control of Rb peturbed in most cancers?
yes
what can activate cyclin D?
• Hh • cytokines (JAK+STAT pathway) • growth factors (via RTKs) • growth factors (via Her/Neu2) • wnts