GGT
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What is the systematic name of GGT?
E.C. 2.3.2.1
The reaaction of GGT happens at what pH?
pH 8.2
What is the mechanism of GGT?
GGT Catalyzes the transfer of gamma-glutamyl residue from gamma-glutamyl peptides to amino acids, other peptides, or H2O
In decreasing order of abundance, where is GGT found?
PRT
The functional unit of kidney
Nephron
- Part of the capillary - Filter of the kidney - Situated in the Bowman’s capsule
Glomerulus
Contains most of our GGT, Liver, Pancreas. Some amounts of GGT can be found in the intestines.
PRT
In chronological order, enumerate the most abundant to least abundant.
Proximal Renal Tubules → Liver → Pancreas → Intestines
What is the half-life of GGT?
7-10 days In alcoholic liver disease: 28 days
What is the main cause of elevated GGT?
The problem that originates from the liver.
At what percent does smoking elevate GGT?
10%
At what percent does medication elevate GGT?
20%
Smoker + alcoholic abuser = elevated GGT
Synergy
Most sensitive marker for alcohol intake
GGT
In the 1st trimester of pregnancy, at what percentage does it elevate?
25%
The increase in GGT in the 1st trimester of pregnancy may reflect changes in __________________?
Liver function + insulin sensitivity.
Elevated GGT during 1st trimester may be at risk of?
developing gestational diabetes mellitus.
These are synthetic hormones target the liver. Therefore, it may cause movement activation of many enzymes not only GGT.
Oral contraceptive
At what percentage do oral contraceptives elevate GGT?
20%
What is the primary use of GGT?
Evaluation of liver injury
Most widely used substrate in GGT analysis
Gamma-glutamyl-p-nitroanilide
What sample is also preferred aside from none hemolyzed sample?
EDTA BLOOD PLASMA PREPARED FROM EDTA
Why is heparin not a preferred sample?
May cause turbidity to the reaction mixture
Why is Citrate, Oxalate and Fluoride not a preferred sample?
can cause false decrease in the concentration of GGT by about 10- 15%