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Bone is a type of ?
dense connective tissue
The bones Can be found in the range of ?
lightweight to strong
Bone contains both ?
organic and inorganic material.
What is the major organic matter found in bone ?
Proteins
What is the major protein of bones ?
Type I collagen
What is the The major inorganic or mineral component ?
calcium phosphate
Bone has a dynamic structure that undergoes continuing cycles of ?
remodeling
its role is to maintain bone matrix ?
Osteocytes
involved in bone deposition ?
Osteoblasts
involved in bone resorption ?
Osteoclasts
What is the enzyme that expels protons across the border into the resorption area ?
a proton-translocating ATPase
What is the enzyme that digest the now accessible matrix proteins ?
Lysosomal proteases
Osteoblasts – are ?
immature bone cells
Osteoid protein primarily composed of ?
Type I collagen
What is the enzyme in the Osteoblasts that generate phosphate ions from organic phosphates ?
alkaline phosphatase
sialoproteins contain motifs as ?
poly-Asp & poly-Glu stretches
What is the inhibitors of mineralization ?
glycoproteins and proteoglycans
Osteocytes Originate from ?
osteoblasts
mechano-sensory receptors , stress and mechanical load ?
Osteocytes
What is the inhibit osteoclasts ?
calcitonin
What is the stimulate osteoblasts ?
growth hormone (GH), parathyroid hormone (PTH), vit D & also sex hormones
Growth factors are most important in ?
making bone
What is the stamulates insulin-like growth factor-1 , IGF-I ?
GH, PTH & E2 (estradiol) promotes
What is the major organic matter found in bone ?
Proteins