Colloids
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What are colloids in simple terms ??
They are tiny particles that are not too big or small that float in a liquid
What are colloids ?
They are disperse systems with particles between 1nm and 1mm in size
Why do collides have a unique property?
The small particles create a large surface area relative to the volume
What do you collides help make in pharmacy?
Drug delivery systems Controlled release medicines Nano particles/micro particles
What are collides based on?
Their affinity for dispersing mediums
What are the two main types of collides?
Lyophilic and lyophobic
What are the key points about lyophilic collides ?
They mix easily with water Very stable
What are lyophilic collides known as in aqueous systems ?
Hydrophilic collide as they mix easily with water
What are examples of lyophilic collides?
Proteins ,gums, phospholipid vesicles, micelles formed by surfactants
What are phospholipid vehicles also known as?
Liposomes
How are lyophilic collide stable?
Lyophilic colloids are stable due to strong solute–solvent interactions, which cause extensive hydration of the dispersed particles, making the system thermodynamically stable as high affinity
What are the main points about Lyophobic collide?
Do not mix well with water Unstable and needs stabilises or the same charge
What are lyophobic collides known as in an aqueous systems ?
Hydrophobic collides as they do not mix well with water
What are examples of lyophobic collide?
Insoluble drugs, oily drugs, clays
Why are lyophobic collides unstable?
They are thermodynamically unstable and tend to cluster to reduce the surface energy so rely on surface charge and added stabilisers because of poor solute solvent interaction as low affinity
What are the three types of pharmaceutical systems that collide appear in ?
Emulsions Suspensions Aerosols
Give me examples of emulsions that collide appear in ?
Creams Parental nutrition- feeding directly into bloodstream not stomach
Give me examples of suspensions that collides appear in ?
Oral or injectable drugs
Give me examples of aerosols that collide appear in ?
Inhalers for asthma
What are example examples of biological collide?
Cells, blood and platelets which be behaved similarly to synthetic colloid dispersion which are man made colloids
What do collide in suspensions look like?
Tiny solid particles
What do collide in emulsions look like?
Drops of oil in water
Tell me about the stability of collides?
Collide can fall apart if particles stick together so they stay stable due to electrostatic repulsion and steric repulsion
What are the two forces that stabilise collide?
Electrostatic repulsion Steric hindrances