Liver Function

Blood is supplied to the liver by the _________ _________ and hepatic portal vein.

______ flows from hepatocytes, via canaliculi and ductules, to form hepatic ducts.

The liver is organised into functional units are called ___________.

What shape is each hepatic lobule?

____________ are arranged into irregular, branching, interconnecting plates around the hepatic vein.

Portal ________ lie at each ‘corner’ of the liver lobule.

How do hepatocytes generate energy?

____________ contain proteolytic enzymes.

What is the role of hepatic endoplasmic reticulum?

List two functions of the liver.

List three functions of the Golgi complex.

Gluconeogenesis, glycogenesis and glycogenolysis, together with _________ ______ metabolism are major liver functions.

Name three substances that are detoxified and/or excreted by the liver.

Red cells are removed from the circulation by the ______________ _________ of the liver and spleen.

True or false: unconjugated bilirubin is insoluble.

Unconjugated bilirubin is transported while bound to _________.

Unconjugated bilirubin can cross the blood-brain barrier, and is therefore potentially _________.

If not bound to albumin, unconjugated bilirubin is ______-soluble

Bilirubin is taken up by ____________ and conjugated (in ER) to mono- and diglucuronides.

Normal bile is comprised of 25% _______________ and 75% diglucuronides.

Conjugated bilirubin is soluble, and is converted to _______________ by GIT bacteria.

True or false: all urobilinogen is reabsorbed.

Most urobilinogen is oxidised in gut to a brown pigment (______________) and excreted.

Unconjugated bilirubin is not filtered by the ______________.