W10 - Nutrient Interactions
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What can medication do to nutrient absorption?
⬇️ or prevent it
What is a chelation reaction?
Metal ion + organic complexing agent –> Ring structure encompassing the metal ion + removes it.
What do chelation reactions between medications + minerals (metal ions) do? What is the advice that follows this?
⬇️ amount of mineral avail. for absorption. Advice - Take minerals at least 2 to 6 hrs apart from drug.
What is adsorption?
Adhesion of atoms, ions or mol from a gas, liquid or dissolved solid to a surface. Creates a film of the adsorbate on the surface of the adsorbent.
What is absorption?
Fluid (absorbate) is dissolved by or permeates a liquid or solid (absorbent).
What can adsorption do to nutrient absorption?
⬇️ it
What drug is known to treat diarrhoea?
Bile acid sequestrant cholestyramine (Questran)
What does Bile acid sequestrant cholestyramine (Questran) do?
ADSORBS fat-sol vitamins A,D,E+K.
What does it mean that Bile acid sequestrant cholestyramine (Questran) adsorbs A,D,E+K?
Should recommend vitamin supplementation w/ LT use of this drug, especially when taken more than once a day.
Bile acid sequestrant cholestyramine (Questran) What vitamin supplementation is recommended?
30ml + of mineral oil/ day = ⬇️ absorption of vit A,D,E+K It is advised to take the mineral oil a.m + vitamins 2+hrs later.
How can drugs reduce nutrient absorption?
By influencing transit time of food + nutrients in gut.
What reduce transit time of food + nutrients in the gut?
Cathartic agents + laxatives
What can cathartic agents + laxatives cause? What can this then lead to?
Diarrhoea Loss of Ca2+ + K+.
What else can diarrhoea be induced by?
Drugs containing sorbitol, i.e syrup or solution forms of furosemide. Drugs that ⬆️ peristalsis, i.e Cytotec.
How might a drug prevent nutrient absorption?
By changing the GI env.
What might antisecretory drugs be used to treat?
Ulcer disease + GERD.
How do antisecretory drugs treat Ulcer disease + GERD?
Inhibit gastric acid secretion + ⬆️ gastric pH. == Impairs absorption of V B12 by ⬇️ cleavage from its dietary sources.
What do the drugs do that have the biggest effect on nutrient ABSORPTION?
Those that damage the intestinal mucosa.
Damage to the intestinal mucosa
Damage to the structure o the villi + microvilli inhibit the brush-border enzymes + intestinal transport systems involved in nutrient absorption.
What does damage to the gut mucosa commonly result from?
Nonsteroidal anti-inflammatory drugs (NSAIDs) LT antibiotic therapy
What is the science of nutrigenomics?
Science of nutrients + the genes. How naturally occurring chemicals in foods can alter mol expression of genetic info in each ind.
What does nutrient intake affect?
Genomics Proteomics Metabolomics == Then impacting disease prevention + +ive health outcomes.
What is genomics
Make up of genes + the gene expression
What is proteomics
Creation of the gene