transition from academia to reseach
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what are the 4 stages of research
-basic science -translational research -efficacy study -outcomes and effectibeness research
what do you need to start a lab
A good project Your own ideas Funding
what do you need to survive to survive running an academic lab
More funding Great graduate students and post-docs New ideas Innovation Collaborations (academic and industry)
true or false: in running an academic lab you are the boss
yeah
true or false: grant funding rates keep going lower
true
running an industry lab: what u need to start
-Drive to make a difference Flexibility Patience
running an industry lab: what u need to survive
A great research team New ideas Innovation More patience Adaptability Collaboration
running an industry lab, you decide what
who you hire how projects progress (with boss) priorities which projects to stop (not always) who to collaborate with or not
what are the 3 hats that a pi wears in an industry lab
-Principle investigator Writer / editor Committee member
Lead discovery then seeks to identify a drug-like small molecule termed a …..
development candidate that will progress into preclinical and then clinical development
what are the main reasons for rnd failure
-thoxology/safety issues -lack of efficacy -pharmacokinetics -commercial reasons
what do biologists do in rnd
Develop assays and reagents Explore target biology and MOA Test compounds in relevant in vitro assays
what do pharmacologist do in rnd
test compounds in relevant in vivo models
what do medicinal chemists do in rnd
make tool compounds needed for in vitro and in vivo testing
what do analytical chemists do in rnd
evaluate the physiochemical and pharmokinetics of compounds
In industry you will
-Be required to work within the business and scientific strategy of the company and not be solely guided by your own scientific interests Be asked to pivot to new projects quickly Be required to participate in and present at cross-functional meetings where data is vetted, and the future directions of a project are established by discussion and consensus
true or false: biotech is usually more innovative, high-risk scientific approaches
true while big pharma is usually more of a pussy behavior
true or false: big pharma is usually more hierarchical
true biotech is more chill
true or false: in biotech they have more resources than Academia, but often partners with Pharma for expensive late-stage clinical programs
true
true or false: big p0harma can be aquiried and have periodic layoffs
true but more stable usually
true or false: in biotech more opportunities for advancement than Academia or Pharma if company grows
true -Stock options can provide financial windfall if company successful
true or false: in big pharma it takes longer to have a promotion
true