drug elimination
No description yet. This curated deck is ready for daily study.
Card preview (9)
elimination
irreversible loss of drug by excretion and/or metabolism
excretion
irreversible loss of chemically unchanged drug. - mainly via kidneys - also: bile, sweat, saliva, air, milk
metabolism
conversion of the drug into a different chemical species (biotransformation) - mainly by liver - also: lungs, gi wall, blood, skin, kidney
what can drug elimination help you understand?
• find drug conc after taking medicine • find how liver disease affects drug conc • find interactions between drug and drugs, drugs and food, herbal products • find variability in drug therapy in terms of age + genetics
what is clearance (Cl) ?
elimination process for each drug is describing and quantified by its clearance
define clearance
• the proportionality factor that relates the elimination rate of a drug with the drug concentration in blood (plasma) • elimination rate of drug = clearance x Cdrug (mass/time) = (volume/time) x (mass/volume) • volume of fluid that is completely cleared of drug per unit time
units for clearance
volume/time (mL/min or L/h)
what does Cldrug = 15mL/min mean?
15mL of plasma are cleared of drug every minute