Documentation, records and ethical applications
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Name some permissions, records and regulations you need when you want to work with animals
• permission to use animals for research • facility permission • breeding permission • GMO permission • Import permission • permission to use animal by-products (organs etc) • transportation permit + education • ethical approval • statistical records • animal records • proof of education • standard operating procedures • know your legislation
For which species do you need a purpose breeding permission?
• every species if GM vertebrate • rodents, rabbits, ferret, cat, dog and quail • primates • GMO-animals • zebrafish and amphibians
Name five allowed invasive methods for ID marking of animals
• tattooing • freeze marking • ear tags • microchips • mouse, rat, hamster, garbil, veil and guinea pigs may also be marked with ear marking by scissors
What information is required in animal records?
• permission number for research and ethics permit/breeding permit • stored at animal facility for 5 years • ID • husbandry • care and supervisor • born or wenaed date or arrival date • medical record • if found dead: date, cause, signature • if sold: date, receivers name and address • experimental procedures + date + signature • humane endpoints • end of experiment • assessment level of pain/discomfort • in case of re-use: date + signature from vet
Name the tasks of the swedish regional ethics committees
• evaluate scientific valitidy • evaluate welfare cost to the animals • evaluate ethical considerations
What are the levels of grading of discomfort and pain?
• terminal/ organ –> euthanasia for organs • terminal • mild • non-recovery acute operation • moderate • severe
Describe what the “mild” grading of discomfort and pain includes
• Blood sampling in peripheral vessels • Studies done on anaesthetized animals that will be euthanised without waking up • injections with non-irritating substances
Moderate grading of discomfort and pain
• major surgical procedures where the animal will wake up and with appropriate post operative care and pain relief • injections with irritating substances • adding several mild procedures will make it moderate
Severe grading of discomfort and pain
• major surgical procedures on anaesthetized animals without adequate post op pain relief • causing severe diseases without any treatment regime to ease the suffering • adding several moderate procedures will make it severe
Which parts are included in the ethical application form?
• general information: staff, project leader… • aim • species • projectplanning
What kind of procedures should be included in the application?
• All! • Everything that is not mentioned in the plan is not allowed to be performed!
For which types of research applies specific regulation?
• immunisation • research on experimental joint diseases in rodents • tissue sampling for gene expression • toxicity testing • generation of GMO animals
The UU template for health assessment consists of two parts. Which?
• for use before experiment starts and during breeding of non-GMO animals • Extended. After research starts and breeding of GMO animals
Functions/organs included in the health assessment
• general condition • exudate of prophyria and/or eye inflammation • movement and posture • piloerection • respiration • skin • weight (added in extended) • appetite (added in extended) • urinary and bowel function (added in extended) • body scoring in cancer research
For which animals is ID marking mandatory?
• Primates • Dogs • Cats • Rabbits • Farm animals