L-2 The immune system
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susceptibility
lack of resistance to a disease
immunity
ability to ward off disease
innate immunity
defences against any pathogen
adaptive immunity
adaptive resistance to a specific pathogen
facts about innate immunity
• nonspecific defence mechanism • provides immediate defence against infection • come into play immediately • include physical barriers ( skin, proteins in blood and immune cells)
inflammation
• first response of the immune system to infection • stimulated by chemical factors released by injured cells
whats PRR
Pattern recognition receptors
whats PAMP
Pathogen associated molecular patterns
inflammation signs
redness swelling heat pain mucus
what inflammatory mediators do cells release
histamine serotonin prostaglandins bradykinin leukotrienes
what are toll like receptors and example
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors • RNA/DNA virus • gram positive/negative • fungi / protists
where are toll like receptors found
macrophages mast cells dendritic cells
what does nod stand for
Nucleotide-bindingn Oligomerisation Domain
what do Nod-like receptors do
sense infection and stress through the recognition of cytoplasmic PAMPs
other innate immune receptors
host anti viral responses - RIG I Like receptors - Cytosolic DNA sensors anti0fungal responses - C type lectin receptors
cells of the innate immune response
phagocytes neutrophil dendritic cells mast cells basophils eosinophils natural killer cells t-cells
whats the complement system
the ability of antibodies and phagocytic cells to clear pathogens from an organism
what immunity is only found in vertebrates
adaptive immunity
what are antigens
substances that can evoke a response from a B or T cell
whats the small accessible part of an antigen that binds to an antigen called
epitope
antigens example
intracellular antigens extracellular antigens dendritic cells lymph nodes
adaptive immune cells
B,T,Natural killer cells antibodies
where does T-cell mature where does B-cell mature
thymus spleen and SLO ( secondary lymphoid organs)
antibody function
do not kill pathogens they mark pathogens for destruction neutralisation