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W9 - Detox Pathways in Liver

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

List some functions of the liver

Back (Answer)

Detoxification Protein synthesis Prod biochemicals needed for digestion + growth Reg. glycogen storage, decomposition of RBCs + prod of hormones

#2
Front (Question)

Where is the liver found?

Back (Answer)

Right upper quadrant of abdomen Below diaphragm

#3
Front (Question)

Where is the gallbladder?

Back (Answer)

Under liver

#4
Front (Question)

What does the gall bladder do?

Back (Answer)

Stores bile produced by liver b4 passing it onto small intestine to be used in digestion.

#5
Front (Question)

How does the liver protect the body from lipophiles?

Back (Answer)

Converts them into more H20 soluble metabolites that can be removed via urine.

#6
Front (Question)

What are the 2 pathways in liver detoxification?

Back (Answer)

Phase I Phase II

#7
Front (Question)

What is Phase I known as?

Back (Answer)

1st line of defence vs toxins

#8
Front (Question)

What enzyme family does Phase I have?

Back (Answer)

Cytochrome P450 enzyme family

#9
Front (Question)

What does the Cytochrome P450 enzyme family help do?

Back (Answer)

Neutralise substances like alcohol + caffeine.

#10
Front (Question)

Can the byproducts of phase I liver detoxification pose a toxic threat to the body still?

Back (Answer)

Yes

#11
Front (Question)

What can happen if toxins are allowed to build up + stay in the liver?

Back (Answer)

Can damage DNA + proteins.

#12
Front (Question)

What is the purpose of Phase II?

Back (Answer)

Neutralises byproducts of phase I + other remaining toxins.

#13
Front (Question)

What is the term under phase II?

Back (Answer)

Conjugation – Making toxins H20 soluble ready to be excreted from the body

#14
Front (Question)

What are the primary molecules responsible for conjugation in Phase II?

Back (Answer)

Glutathione (a.k.a master antioxidant) Sulphate Glycine

#15
Front (Question)

Which is the most abundant antioxidant?

Back (Answer)

Glutathione

#16
Front (Question)

What can Glutathione do?

Back (Answer)

Regenerate itself in the liver

#17
Front (Question)

In what foods can Glutathione be found?

Back (Answer)

Asparagus Avo Spinach Broccoli

#18
Front (Question)

List some of the key building blocks the body needs to manufacture Glutathione

Back (Answer)

Selenium Vitamin E

#19
Front (Question)

What is vitamin C role in liver detoxification?

Back (Answer)

Helps protect liver detoxification enzymes from oxidative damage

#20
Front (Question)

What does it mean that the majority of toxic substances are fat-soluble?

Back (Answer)

Means they can sequester in tissues + accumulate in the body?

#21
Front (Question)

Body converts fat-soluble toxins into H20-soluble mol to be excreted through what routes?

Back (Answer)

Renal or biliary

#22
Front (Question)

What are the major detox organs?

Back (Answer)

Kidney + liver

#23
Front (Question)

What are the phases also known as?

Back (Answer)

P1 = Oxidation phase P2 = Conjugation phase

#24
Front (Question)

List some examples of detox programmes

Back (Answer)

Fasting Eating only certain foods Sauna Red. env exposures