Muscle Histology
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Types of Muscles
Striated (skeletal and cardiac) and Smooth (no striations, involuntary)
What is skeletal muscle
Striated muscle attached to bone, move the skeleton • Fibers = multinucleated cells • Voluntary contractions
What is cardiac muscle
Striated muscle in wall of heart, involuntary contractions
Skeletal Muscle
• Consists of long multinucleated muscle fibres • Contains myofibrils, containing thick actin and thin myosin filaments
Sarcomeres
Sarcoplasmic reticulum
Depolarisation of T tubule membrane triggers Ca2+ to release, Ca2+ binds to troponin-tropomyosin complex to initiate muscle contraction Muscle relaxes when Ca2+ concentration in cytosol decreases
What does the neuromuscular junction have to do with this
• Where axon ends and joins to muscle fibre • Contains neurotransmitter ACh
Contraction visualisation
Cardiac Muscle
Contain intercalated disks
Cardiac Muscle Contraction
Smooth Muscle
Smooth Muscle Contraction
Comparison table 1
Comparison table 2
Muscle injury and repair comparisons
Microscopic comparisons
