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Exam 3 - Lecture 30, Opioids

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

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#1
Front (Question)

Opiate

Back (Answer)

defines drugs derived from opium, including semi-synthetic derivatives of morphine

#2
Front (Question)

Opioid

Back (Answer)

term for all agents, natural and synthetic, with morphine or opium-like actions

#3
Front (Question)

Endogenous opioid peptides are

Back (Answer)

the group of endogenous peptides with opioid actions; natural ligands for opioid receptors

#4
Front (Question)

Narcotic

Back (Answer)

Legal designation for opioid drugs and other drug of abuse that produce stupor and insensibility medically defined as drugs with sedative/hypnotic and analgesic properties

#5
Front (Question)

How do opioid drugs produce their effects?

Back (Answer)

Stereospecificity - Levo isomers are active form Saturability - finite number of sites; receptor occupancy determines magnitude of agonist effect Competitive inhibition of binding by antagonists inhibits opioid effects Affinity of receptor for opioid drugs correlates with their analogies potencies clinically

#6
Front (Question)

Four opioid classes

Back (Answer)

Enkephalins Endorphins Endomorphins Nociception/ Orphanin FQ

#7
Front (Question)

Enkephalins derived from

Back (Answer)

proenkephalin

#8
Front (Question)

Forms of Enkephalin

Back (Answer)

Methionine - enkephalin (H-tyr-gly-gly-phe-met-OH) Leucine - enkephalin (H-tyr-gly-gly-phe-leu-OH)

#9
Front (Question)

Endorphins

Back (Answer)

larger polypeptides than enkephalins but contain in their sequence met-enkephalin

#10
Front (Question)

Prodynorphin yields

Back (Answer)

dynorphin A, B, and a-neoendorphin

#11
Front (Question)

Pro-opiomelanocortin yields

Back (Answer)

B- endorphin

#12
Front (Question)

Endomorphins derived from

Back (Answer)

unknown source currently

#13
Front (Question)

Form of Endomorphins

Back (Answer)

Endomorphin 1 = Tyr-Pro-Trp-Phe-NH2 Endomorphin 2 = Tyr-Pro-Phe-Phe-NH2

#14
Front (Question)

Nociceptin/Orphanin FQ

Back (Answer)

17 amino acid peptide derived from pronociceptin Considered the natural ligand for the ORL1 (OP4) opioid receptor

#15
Front (Question)

Opioid analgesia mediated in (Descending inhibitory pathway)

Back (Answer)

Mediated in dorsal columns of spinal cord, periaqueductal gray, raphe nucleus (5HT containing neurons)

#16
Front (Question)

Opioids produce analgesia by

Back (Answer)

Inhibiting release of substance P (Pain transmitter) from primary afferent pain fibers in spinal cord (Spinal level) Altering subjective response to pain sensation, probably mediated at higher (supra spinal) centers in brain

#17
Front (Question)

Opioids effect on GI and motility

Back (Answer)

Mediated by stimulation of opioid receptors in nerve plexes and glands of stomach and intestine Can be used as an anti-diarrheal

#18
Front (Question)

Four opioid receptor subtypes

Back (Answer)

Mu Kappa Delta ORL1

#19
Front (Question)

Mu receptors and binding affinity

Back (Answer)

Morphine, prototype agonist Endorphins>enkephalins>dynorphins

#20
Front (Question)

Kappa receptors and binding affinity

Back (Answer)

Ketocyclazocine, prototype agonist Dynorphins>endorphins and enkephalins

#21
Front (Question)

Delta receptors and binding affinity

Back (Answer)

D-ala, D-leu enkephalin, prototype agonist Enkephalins > endorphins> and dynorphins

#22
Front (Question)

ORL1 (opioid-receptor-like receptor)

Back (Answer)

Named after discovery of nociceptin/orpganin FQ, the endogenous ligand for this receptor

#23
Front (Question)

Neurons Expressing D2 show

Back (Answer)

enkephalins

#24
Front (Question)

Neurons Expressing D1 show

Back (Answer)

Dynorphins