Calcium, Phosphorus, and Magnesium
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Increase intracellular calcium results in increased…
Contraction
A decrease in serum magnesium, Causes calcium in serum to…
Go down (Into the cell) 
An increase in serum magnesium Causes _________ in Serum calcium
Increase (Decrease inside the cells) 
Over 300 Enzymatic activity requires magnesium as a…
Cofactor
What is the biologically active form of magnesium?
Ionized/free form (about 70%) 
Is magnesium extracellular or intracellular cation?
Intracellular, influenced by Hemolysis *divalent
Major source of magnesium?
Diet/reabsorbed in intestine
What is the normal value for magnesium in plasma/serum?
1.7-2.2 mEq/L (0. 85-1.10 mmol/L) • Member first number is twice as much
What is the percentages and location of magnesium in the body?***
-bone 50-60% -muscle 20%, intracellular 20% (Cells equals 40%) -Serum 1%
Magnesium in serum, which accounts for 1% of all body magnesium,  is in what forms? 
-ionized about 70% * -Protein associated 25% -Combined ions (Phosphate and citrate) 5%
Steroid hormones don’t need plasma ____________
Receptors
Three mechanisms of allosteric regulator
-changes structure of proteins so substrate cannot bind -physically covers the substrate binding site -Enhances enzymatic activity
What are the functions of magnesium?
-enzymatic reactions, energy storage/transfer/production ** Inhibits calcium entry into cells! * Bone homeostasis (50-60%) 
Magnesium in serum is regulated by…
-parathyroid hormone PTH (Can stimulate reabsorption in intestine and release from bone)  -aldosterone (Increases sodium and decreases potassium), And thyroxine. Aldosterone And thyroxine increase in renal magnesium excretion (Lowers magnesium)*****
What three hormones regulate magnesium?
-thyroxine -Aldosterone -Parathyroid hormone PTH
Mg inhibits __________ entry into the cell
Calcium**
What are symptoms of hyper magnesium?
heart block, vomiting, nausea Sedation, respiratory depression, paralysis,coma 
Causes of elevated magnesium
• adrenal insufficiency: Hypoaldosteronism (aldosterone increases magnesium excretion) • hypothyroidism -Renal Failure -Dehydration (Relative amount, not absolute amount) 
Symptoms of hypomagnesium
-tetany and seizures, decreasing neural transmission, CV abnormalities, weakness, tremors, paralysis,,, psychiatric disorders
Causes of hypomagnesium
• diabetes mellitus (Type two magnesium effects insulin function) • Diuretic therapy • alcoholism -Drug therapy • Hyperaldosteronism (Magnesium gets excreted)
What is the most abundant mineral in the body, fifth most abundant inorganic element
Calcium Too much increases apoptosis 
 ______% of calcium resides in the bone (reservoir), ___% in plasma 
99 1
Of the 1% of calcium in the plasma what percentage is the free ionized form that is biologically active? What percentage is bound to proteins?
45-50 40-50
________-Calcium specific curator ________-Divalent curator that removes calcium and magnesium
EGTA, EDTA