Food intake, Digestion & Absorption
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Resulting products for Pyralin (salivary amylase)
Forms dextrine + branched oligosaccharides
Substrate, action and resulting products for Pepsin
Protein (in the presence of HCL acid) Hydrolysis Polypeptides + aa
Substrate, action and resulting products for Gastric lipase
Fat, esp shorter chain Hydrolysis Free FAs
Substrate, action and resulting products for Lipase
Fat (in presence of bile salts) Hydrolysis Monoglycerides + FAs (incorporated into micelles)
Substrate, action and resulting products for Cholesterol esterase
Cholesterol Hydrolysis Esters of cholesterol + FAs (incorporated in micelles)
Substrate, action and resulting products for a-amylase
Starch + dextrins Hydrolysis Dextrine + maltose
Substrate, action and resulting products for Trypsin (activated trypsinogen)
Proteins + polypeptides Hydrolysis Interior peptide bonds to form polypeptides
Substrate, action and resulting products for Chymotrypsin
Proteins + polypeptides Hydrolysis Interior peptide bonds to form polypeptides
Substrate, action and resulting products for Carboxypeptidase
Polypeptides Hydrolysis Terminal peptide bonds to form aa
Substrate, action and resulting products for Elastase
Fibrous protein Hydrolysis Peptides + aa
What is the cause of GI movement?
Coordinated activity of: • Enteric nerves • Extrinsic nerves • Endocrine cells • Smooth muscle
NEUROTRANSMITTERS GABA Site of release + primary action
CNS Relaxes lower oesophageal sphincter
NEUROTRANSMITTERS Norepinephrine Site of release + primary action
CNS, spinal cord, sympathetic nerves ⬇️ Motility ⬆️ contraction of sphincters Inhibits secretions
NEUROTRANSMITTERS Acetylcholine Site of release + primary action
CNS + Autonomic system ⬆️ Motility Relaxes sphincters Stimulates secretion
NEUROTRANSMITTERS NEUROTENSIN Site of release + primary action
GI tract, CNS Inhibits release of gastric emptying + acid secretion.
NEUROTRANSMITTERS SEROTONIN (5-HT) Site of release + primary action
GI tract, spinal cord Facilitates secretion + peristalsis
NEUROTRANSMITTERS NITRIC OXIDE Site of release + primary action
CNS, GI tract Regulates blood flow Maintains muscle tone + gastric motor activity
NEUROTRANSMITTERS SUBSTANCE P Site of release + primary action
Gut, CNS, skin ⬆️ sensory awareness + peristalsis.
Where is gastrin secreted from?
Endocrine “G” cells in the antral mucosa of the stomach.
What initiates secretion of gastrin?
Distension of antrum after meal Impulses from vagus nerve
When is gastrin inhibited?
When acidity in lumen ⬆️
What does gastrin do?
Binds to receptors on parietal cells + histamine-releasing cells - To stimulate gastric acid To receptors on chief cells - To release pepsinogen To receptors on smooth muscle to ⬆️ gastric motility.
Where is secretin released from?
“S” cells in wall of proximal small intestine into bloodstream
Why is secretin released?
In response to gastric acid + digestive end products in duodenum.