[2S] UNIT 7 HbA1c & Nyco Card

Percentage of HbA

Percentage of HbA2

Percentage of HbAF

A protein in its quaternary structure - larger unit that is made up of tertiary units - made up of 4 polypeptide chains (2a & 2b)

T/F: Glycogen is always found in the extracellular fluid

T/F: Glucose finds a way to the valine terminal molecules

Formation of a hgb compound produced when glucose reacts with the amino group of hemoglobin

GLYCOSYLATED HEMOGLOBIN The glucose molecule attaches non enzymatically to the hgb molecule to form a _______

The rate of formation is directly proportional to the plasma glucose concentration

Reflects the average blood glucose level over the previous 2 to 3 months

Forms the major fraction of adult hemoglobin

T/F: Glycosylated Hemoglobin is tested to measure short-term glucose metabolism

More reliable method of monitoring long-term diabetes control than random plasma glucose

T/F: Current ADA guidelines recommend that an HbA1c test be performed at least 2 times a year with patients who are meeting treatment goals and who have stable glycemic control

T/F: For patients whose therapy has changed or who are not meeting glycemic goals, a quarterly HbA1c test is recommended

T/F: HbA1c testing does not require fasting and is a long term diabetes control

T/F: Glycated hemoglobin is not an antigen

Most to least antigenic molecule

Any type of molecules that invoke an immune response

METHODS BASED ON STRUCTURAL DIFFERENCES Polyclonal or monoclonal antibodies toward the glycated N-terminal group of the b-chain of hemoglobin

METHODS BASED ON STRUCTURAL DIFFERENCES Not affected by other hemoglobins

METHODS BASED ON STRUCTURAL DIFFERENCES Separates based on chemical structure using borate to bind glycosylated proteins

Nobel prize winners: antibodies method Start with B lymphocyte of the mouse and vaccine it with foreign protein to gather antibodies and be utilized as reagent for assays

METHODS BASED ON STRUCTURAL DIFFERENCES Not temperature dependent