test 2

how many types of cancer treatments are there?

focus has shifted from curing cancer to making it a – disease

are targeted therapy and immunotherapy always effective

what type of therapy? targets dividing cells and induces cell death

what type of therapy? diminishes hormone levels or hormone signaling activity in hormone sensitive cancers

what type of therapy? antibody targets a specific protein and results in cell death, blockade of receptor-ligand interactions, or otherwise interferes with necessary processes for the tumor

what type of therapy? vaccine stimulates immune system to detect and remove cancer cells or prevents the induction of cancer by certain infectious agents

what type of therapy? immunomodulatory activity, possible antiproliferative activity

what type of therapy? small molecules that inhibit a specific molecular target that is considered fundamental to the cancer cell survival

what does nitrogen mustard do to DNA?

what is the first successful chemo drug

deficiency in which vitamin/molecule causes anemia?

— inhibit biosynthesis of purines and some amino acids

what type of chemotherapy agent? damage DNA by covalent binding of alkyl groups, preventing cell division and leading to cell death

what type of chemotherapy agent? interfere with DNA replication through a poorly defined mechanism, thought to occur via intercalation into DNA and displacement of DNA binding proteins, or by causing DNA breaks

what type of chemotherapy agent? inhibit DNA replication by causing single and double strand DNA breaks or corsslinked DNA strands

what type of chemotherapy agent? interfere with production of purine nucleotides for synthesis of DNA, preventing cell division (a type of antimetabolite)

what type of chemotherapy? substitute components normally used for inclusion in RNA or DNA, interfering with gene transcription or chromosomal replication and causing damage during S phase, chemical structures are often similar to nucleosides

what type of chemotherapy agent? form covalent intra-strand DNA cross-links, preventing cell divison and leading to cell death

what type of chemotherapy agent? stabilize microtubules, preventing completion of mitosis, leading to cell death

what type of chemotherapy agent? interfere with topoisomerases, which separate strands of DNA for copying during S phase

what type of chemotherapy agent? unlike taxanes, these drugs interfere with microtubule assembly during M phase, preventing cells from dividing

are chemotherapy agents synthetic or natural products?

many chemotherapy agents were developed pre—