lecture 11 - krebs cycle
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what allows pyruvate and NADH to get into the mitochondria
transporters
when in the mitochondria what enzyme acts on pyruvate
pyruvate dehydrogenase
what enzymes make up PDH
-pyruvate decarboxylase -dihydrolipoyl transacetylase -dihydrolipoyl dehydrogenase
what does PDH use as a cofactor
vitamin B1
what does PDH do
• What it does is it catalyses the irreversible oxidative decarboxylation of pyruvate This is important because this is the gatekeeper into the TCA cycle, you are using glucose to generate energy in the TCA cycle, you don’t want to lose any acetyl coA that you make going backwards and then forming some other compounds baclk up the chain, you want it to feed into the TCA cycle, it is kind of like a checkpoint