Endrocrinology
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Chemical messengers in the body to produce biochemical changes; Increase level of activity of a process
Hormone
Major Function of Hormone
Feedback Mechanism
Feedback Mechanism consists of (2)
• Positive Feedback Mechanism • Negative Feedback Mechanism
Decrease in the product; Increases the activity of the system and the production rate
Positive Feedback Mechanism
Increase in the product decreases the activity of the system and the production rate
Negative Feedback
• Each Hormone is produced in a specific Endocrine gland • Hormones are released into blood circulation and carried to site of action as FREE hormone or bound to transport protein • Each hormone acts at a specific site (target organs) to induce certain characteristics, biochemical changes
Characteristics of Hormone
Classification of Hormones by Tissue Origin: TRH, CRF, GnRH
Hypothalamus
Classification of Hormones by Tissue Origin: FSH LH GH PRL TSH ACTH
Anterior Pituitary Gland
Classification of Hormones by Tissue Origin: Vasopressin Oxytocin
Posterior Pituitary Glans (Storage only)
Classification of Hormones by Tissue Origin: Epinephrine Norepinephrine
Adrenal Medulla
Classification of Hormones by Tissue Origin: Cortisol II-Deoxycortisol Aldosterone
Adrenal Cortex
Classification of Hormones by Tissue Origin: T3 T4 Calcitonin
Thyroid
Classification of Hormones by Tissue Origin: PTH
Parathyroid
Classification of Hormones by Tissue Origin: Insulin Glucagons
Pancreas
Classification of Hormones by Tissue Origin: Estrogens
Ovaries
Classification of Hormones by Tissue Origin: Testosterone other Androgens
Testes
Types of Hormone Actions: Act directly upon themselves
Autocrine
Types of Hormone Actions: Act adjuscent to the cells of origin
Paracrine
Types of Hormone Actions: Acts within the cell of origin without exiting the cells
Intracrine
Types of Hormone Actions: Secreted in one location and release into BLOOD CIRCULATION, binds to specific receptor to elicit action
Endocrine
Types of Hormone Actions: Secreted in endocrine cells and remains in relation to plasma membrane Acts on immediately adjascent cells by DIRECT CELL TO CELL contact
Juxtacrine
Types of Hormone Actions: Endocrine cells and interacts with receptors of cells at distant site SECRETED INTO DUCTS
Exocrine
Hormone Classification by Structure: About 2/3 of hormones are proteins or peptides Does not require transport proteins
Proteins/Peptides Insulin, PTH, LH, FSH, TRH, ACTH, Prolactin, GH, Calcitonin, Glucagon, TSH. HCG
Hormone Classification by Structure: Primarily involved in regulation of sexual development and characteristics ; Require Transport Protein
Steroid