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Toxicology (part 2)

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

therapeutic drugs that undergo toxicology

Back (Answer)

Salicylates Acetaminophen

#2
Front (Question)

aka Salicylates

Back (Answer)

Acetylsalicylic acid or Aspirin

#3
Front (Question)

Common analgesic (relieves pain), antipyretic (anti-fever), anti-inflammatory and anticoagulant

Back (Answer)

Salicylates

#4
Front (Question)

Mechanism of salicylates as anticoagulant

Back (Answer)

blocks cyclooxygenase reducing thromboxane and prostaglandins

#5
Front (Question)

Adverse effects of Salicylates

Back (Answer)

Platelet aggregation inhibition GI function interference Rye Syndrome (in children) Viral infection

#6
Front (Question)

Treatment for Salicylates toxicity

Back (Answer)

Neutralization and elimination Maintain electrolyte imbalance

#7
Front (Question)

Salicylates intoxication value

Back (Answer)

Serum lvl: >90 mg/dL 6 hrs after ingestion

#8
Front (Question)

Effects of acute ingestion of Salicylates (high doses)

Back (Answer)

Metabolic acidosis (salicylates are acid) Respiratory alkalosis (direct stimulation of the respiratory center, causing hyperventilation) Inhibits Kreb’s cycle (increases lactate and pyruvate formation → muscle cramps) Ketone formation Death

#9
Front (Question)

Methods for Salicylate measurement

Back (Answer)

Gas Chromatography Liquid Chromatography Chromogenic Assay (Trinder Reaction)

#10
Front (Question)

Has the highest analytical sensitivity for salicylates

Back (Answer)

Liquid Chromatography

#11
Front (Question)

A method for salicylate measurement that uses ferric nitrate to form a colored complex measured using spectro

Back (Answer)

Chromogenic Assay (Trinder Reaction)

#12
Front (Question)

aka Acetaminophen

Back (Answer)

Paracetamol

#13
Front (Question)

a common analgesic

Back (Answer)

Acetaminophen

#14
Front (Question)

Common brand (US) of Acetaminophen

Back (Answer)

TYLENOL

#15
Front (Question)

predicts acetaminophen-induced hepatic damage based on serum conc. of acetaminophen at a known time after ingestion (graphical representation)

Back (Answer)

Rumack-Matthew Nomogram

#16
Front (Question)

Rumack-Matthew Nomogram must not be used in these individuals

Back (Answer)

px. with ethanol abuse (metabolizes acetaminophen at rapid rate)

#17
Front (Question)

Rumack-Matthew Nomogram is used for predicting?

Back (Answer)

acetaminophen-induced hepatic damage

#18
Front (Question)

Effect of Acetaminophen overdose

Back (Answer)

severe hepatotoxicity

#19
Front (Question)

Acetaminophen overdose value

Back (Answer)

300 ug/mL 2 hours after ingestion

#20
Front (Question)

Acetaminophen measurement methods

Back (Answer)

Immunoassay – commonly used HPLC – reference method

#21
Front (Question)

DRUGS OF ABUSE assessed in toxicology

Back (Answer)

Amphetamines Ecstasy Anabolic Steroid Cannabinoids Cocaine (crack) Opiates Phencyclidine Sedatives-Hypnotics OTHERS: Lysergic Acid Diethylamide (LSD) Piperazines Methaqualone (Quaalude) Tryptamines

#22
Front (Question)

can cross the placenta

Back (Answer)

arsenic cocaine

#23
Front (Question)

Most common Amphetamines

Back (Answer)

SHABU

#24
Front (Question)

drug of abuse with ↓ therapeutic dose; very close to toxic dose

Back (Answer)

Amphetamines