Lecture 15
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what is paraza
-mtl canada based, fully integrated preclinical drug discovery company committed to the discovery and delivery drug candidates for client partners
when was paraza was established
2011
scientific areas of expertise within paraza
-chemical sciences -biology -drug metabolism and pharmacokinetics (DMPK)
true or false: most biotech companies get to clinical trials
false: most don’t have enough money so the biotechs give the license to pharma to do the trials
biotech companies are funded by investors which are typically what ?
venture capital companies
how do biotech companies get money after being funded by venture capital companies
they get a payout when projects are licensed ot the company enters the stock market or is purchased
true or false: most biotech companies brought products all the way to market and then become pharma companies like gilead, amgen, biogen
false: a few companies
pharmaceutical companies ern income from what?
-portfolio of marketed products and invest some profits in r&d
r&d historically performed where
in-house from target id through product lunch
today both pharma and biotechs outsource most or their r&d to what
contract research organizations aka CROs
what is a cro
-a company that provide services to biotechs and pharma companies -work is performed for immediate payment rather than as investment for future profit from sales
true or false: a cro needs to be a big company
nah usually it can start as small and then grow as a business develops
how many cros in canada and mtl
-850 in canada -200 located in mtl area
true or false: only biotechs use cros
nah pharma usually can also use cro -some cros in india and china make whole ass buildings to house hundreds of employees dedicated to one company
true or false: big biotechs are the ones that use the most cros
nah usually it is small biotechs -they usually have more dry lab things and they use cros for wet lab
true or false: cros are more expensive for biotechs
nah cros are less expensive and faster because you already have the space for the employees -also some companies have like a chemistry department but not a bio department
what is the biggest departmnet at saraza
medical chemistry department
true or false: the chemical development dep makes small quantities
false: they make a shit ton of chemicals
chemical department expertise
-api synthesis -natural products and analogs -stable label isotopes -fluo dyes -electrochemical transformation -peptide and parallel synthesus
medical chemistry in sarasa
-non classical modalities
true or false: saraza uses computers in medical chemistry
-yeah computer aided drug design
true or false: the bio dep in saraza are specialized in in vitro pharmacology
false: in vivo pharmacology
what does dmpk dep do in pharmacology
-in vitro -in vivo -bioanalysis -tailored adme screening
what are the core paraza capabilities and expertise
-target id and validation -hit identification -lead identification -lead optimization -candidate selection