Clinical Significance of Lipase (Reporting | M)
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What is the difference of LPS bet AMS?
LPS is highly sensitive and sp > AMS
What are the fxns of LPS?
1) It is used to diagnose acute pancreatitis 2) It works together w/ bile (whereas it fxns in the digestion of fat)
In connection to the fxn of LPS, what happens if LPS lvls in the pt is not enough?
The pt’s body will have trouble absorbing fat and important soluble vitamins
What are the important soluble vitamins that the pt’s body will have trouble absorbing if the pt’s LPS lvls are not enough?
Vitamins: 1) A 2) D 3) E 4) K
What is the characteristic of acute pancreatitis?
It is sometimes difficult to be diagnosed
What is the result if the pt’s LPS lvls are not enough?
The pt will exp poor fat absorption (including diarrhea) and fatty bowel movements
Why is acute pancreatitis sometimes difficult to be diagnosed?
Because it is needed to be diagnosed properly in separation to acute intra-abdominal disorders w/ similar clinical findings w/ acute pancreatitis
What are the acute intra-abdominal disorders / conditions that are clinically similar w/ acute pancreatitis?
1) Perforated gastric or duodenal ulcer 2) Intestinal obstruction 3) Mesenteric vascular obstruction
If AMS and LPS lvls are both elevated, what is the difference between the 2?
LPS is elevated longer > AMS
Since LPS is elevated longer > AMS, where can LPS be used?
LPS is recommended for use in emergency cases
What are the conditions / disorders that cause increased lipase?
1) Hyperlipasemia 2) Pancreatitis 3) Peptic ulcer 4) Cholecystitis
What are conditions / disorders related to hyperlipasemia?
1) Increased multiple-organ dysfunction sores 2) Hypotension 3) Anemia 4) Mechanical ventilation (MV) 5) Bacteremia 6) Elevated LFT results 7) Elevated crea and TAG lvls
What is pancreatitis?
It is the condition of redness and swelling (inflammation) of the pancreas
What is the characteristic of pancreatitis?
It may be sudden (acute) or ongoing (chronic)
What are the most common causes of pancreatitis?
1) Alcohol abuse 2) Lumps of solid material (gallstones) present in the gallbladder
What are the characteristics present in chronic pancreatitis?
1) Gallstones and calcifications present in the dilated pancreatic duct 2) Presence of inflamed pancreas
What are the characteristics of acute pancreatitis?
1) Presence of gallstones blocking the pancreatic duct 2) Presence of inflamed pancreas
What is peptic ulcer?
It is an open sore in the stomach lining or the upper part of the small intestine (duodenum)
What are the characteristics of peptic ulcer?
An ulcer can go through all the layers of the digestive tract and form a hole (perforation)
If an ulcer forms a hole in the digestive tract, what is it called?
Perforated ulcer
What is cholecystitis?
It the redness and swelling (inflammation) of the gallbladder
When and how does cholecystitis occur?
It happens when a digestive juice called bile gets trapped in the gallbladder
What are the conditions / disorders that causes decreased lipase?
1) Cystic fibrosis 2) Sx storage 3) Hemolyzed sxs
How can cystic fibrosis cause decreased LPS lvls?
Damage to the cells of the pancreas w/c make LPS is present, hence, resulting to decreased LPS lvls