L4 - role of dosage forms & excipients

hard to give same dose if rug used in powder form

means by which drug molecules are delivered to sites of action within body

• accurate dosing • protection and Shelf-life • protection from gastric juice • masking taste and odour • placement of drugs directly within body tissues • sustained release medication. • controlled release medication. • insertion of drugs into body cavities • use of desired vehicle for insoluble drugs

everything other than api

poor flow/ compressibility

film coating

• tablet • excipients include: • diluents, binders, glints, dry lubricants • disintegrants • sweeteners etc

• stable drug • bioavialble drug • uniform drug content • resistant to disintegration • pleasant

uncoated tablets with acid substances + bicarbonates which react with water to form co2. - rapid dissolution - lubricant needs to be water soluble - tablet packaging critical for stability

formulation contained in gelatine or matrix - masks taste • hard shelled • soft shelled

• solid dry aggregates of powder • placed on tongue, swallowed with water • some dissolve in water before taking

• solid dosage form that dissolves in oral cavity • no water needed • orodispersible tablets • tablet disperses in saliva

clear liquid preparations

oil in water dispersions

API in vehicle

conc aq sol of sugar

clear liquid of potent or nauseous drugs

• viscous liquid oral prep • for coughs • lots of syrup

liquid prep

semi solid, viscous, greasy

less greasy

provide oily barrier which reduces water loss from stratum corneum

semi solid system where liquid phase is in matrix

controlled release of drug