[LEC] Liver Enzymes
No description yet. This curated deck is ready for daily study.
Card preview (24)
5 MAJOR LIVER ENZYMES
AST ALT GGT ALP 5’ NTP
RECOMMENDED NAME OF AST
ASPARTATE AMINO TRANSFERASE
ENZYME CLASS OF AST
TRANSFERASE
EC CODE OF AST
2.6.1.1
SYSTEMATIC NAME OF AST
L-ASPARTATE-2-OXOGLUTARATE AMINOTRANSFERASE
FORMER NAME OF AST
SGOT SERUM GLUTAMIC OXALOACETIC TRANSAMINASE
COENZYME OF AST
PYRIDOXAL PHOSPHATE
CHEMICAL REACTION OF AST
ASPARTATE + ALPHA-KTOGLUTARATE <—AST—> OXALOACETATE + GLUTAMATE
WHICH ENZYME HAS A SHORTER HALF LIFE AST OR ALT
AST
IN AST, ALPHA KETO ACIDS ARE OXIDIZED BY WHAT REACTION
TCA CYCLE TRICARBOXYLIC ACID CYCLE
WHAT DOES THE TCA CYCLE PRODUCE
ENERGY
MAJOR TISSUE SOURCES OF AST
CARDIAC TISSUE LIVER SKELETAL MUSCLE
MINOR TISSUE SOURCES OF AST
KIDNEY PANCREAS ERYTHROCYTES
ISOENZYME FRACTIONS OF AST
CYTOPLASM — Predominant form; found in healthy sera MITOCHONDRIA — Abnormal; found in cellular necrosis
IS AST ISOENZYME ANALYSIS ROUTINELY DONE
NO
CLINICAL SIGNIFICANCES OF AST
HEPATOCELLULAR DISORDERS SKELETAL MUSCLE INVOLVEMENT ANGINA PECTORIS
AST IS USED TO FOLLOW THE COURSE OF WHAT CLINICAL CONDITION
MYOCARDIAL INFARCTION — But is not used to diagnose
PREDOMINANT AST ISOENZYME FORM
CYTOPLASMIC AST
ISOENZYME OF AST THAT APPEARS WHEN CELLULAR NECROSIS OCCURS
MITOCHONDRIAL AST
PATIENT IS DIAGNOSED WITH CHRONIC ALCOHOLISM, WHAT AST ISOENZYME IS INCREASED
MITOCHONDRIAL AST
CYTOPLASMIC AST IS FOUND IN PATIENT X’S SERUM SAMPLE. IS THE PATIENT SUFFERING FROM ANY CLINICAL CONDITION
NO CYTOPLASMIC AST IS FOUND IN HEALTHY HUMAN SERA
EFFECT OF ALCOHOL ON HEPATOCYTES
ALCOHOL DESTROYS HEPATOCYTES MITOCHONDRIAL AST INCREASES
THE TWO MAIN ENZYMES USED TO MONITOR HEPATOCELLULAR DISORDERS
AST ALT
TRUE OR FALSE AST IS USED IN THE DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
FALSE