Toxicology MCQ
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The Trinder reaction is widely used for the colorimetric determination of
Salicyclate
Reinsch test can detect poisoning
Arsenic
The confirmatory method for identification of drugs in body fluids is
GC-MS
Which of the following serum components is able to alter the free drug level in plasma?
Albumin
All of the following statements are true regarding drug distribution patterns except A. Drug metabolism is slower in newborn thana dults. B. Drug metabolism ismore rapid for 6-year old children than for adults. C.Renal clearance of drugs is faster in newborn than adults. D. Drug metabolism often changes during pubescence.
C.Renal clearance of drugs is faster in newborn than adults.
When is a blood sample for the determination of the trough level of a drug appropriately drawn?
shortly before drug administration
Free drug levels can generally be determined by analyzing what body fluid?
Plasma ultrafiltrate
An epileptic patient receiving phenytoin develops acute glomerulonephritis (AGN). What change, if any, would be expected in the patient’s circulating drug level?
increase in free drug
In what form must a drug be in order to elicit a pharmacologic response?
Free
What are the approximate half-life periods for a serum drug concentration to reach 97-99% of the steady- state?
5-7
The first-pass effect after oral administration occurs in the
Liver
The study of what the body does to the drug is
Pharmacokinetics
The route of drug administration with 100% bioavailability is via
IV
The study of what the drug does to the body is
Pharmacodynamics
The route of drug administration with the least bioavailability is via
Rectal
The study of drug action or effects is
Pharmacodynamics
The painless route of drug administration is via
Intranasal
Which of the following drugs is used as bronchodilator?
Theophylline
What is the active metabolite of the antiarrhythmic drug procainamide?
NAPA
What is the recommended name for diphenylhydantoin?
Phenytoin
Which of the following is an example of a phenothiazine drug?
Chlorpromazine
Which of the following is used to treat manic depression?
Lithium
What is the major active metabolite of the anticonvulsant drug primidone?
PEMA
Which of the following is the most commonly encountered xanthine that could potentially interfere with the determination of theophylline?
Caffeine