integumentary system
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epidermis
• outermost layer of skin • made mostly of keratinocytes • keratinocytes start at the stratum basal and move upwards as they mature
layers of the epidermis ( deepest to most superficial)
• Stratum basale • Stratum spinosum • Stratum granulosum • Stratum lucidum • Stratum corneum
stratum basale
• single layer of cuboidal/columnar cells • deepest layer • attached to the basement membrane • most nourished cuz its closest to the blood supply • site of cell division (mitosis)
stratum spinosum
• 8 to 10 layers of spiny keratinocytes • connected by desmosomes (tight connections that prevent tearing) • limited cell division • contains langherans cells (immune cells)
stratum granulosum
• 2 - 5 layers of flattened cells • cells contain keratohyalin granules (cells that make skin impermeable) • nuclei start to breakdown (cells are dying)
stratum lucidum
• only in thick skin (palms and soles) • 2 - 5 layer of dead keratinocytes • contains eleidin (translucent, water resistant protein)
stratum corneum
• top layer • 15 to 30 layers of dead keratin filled cells • main function is to prevent water loss + protect the body
epidermis cell types
• keratinocytes • melanocytes • langerhans cells • Merkel cells
keratinocytes
• most common skin cell • make keratin which strengthens and waterproofs skin
melanocytes
• make melanin • protect against UV radiation • stratum basale
langerhans cells
• immune cells • phagocytes
merkel cells
• touch receptors • located in stratum basale
dermis cell types
• fibroblasts • adipocytes • macrophages • mast cells
fibroblasts
• make collagen, elastin and matrix • main builders of the dermis
adipocytes
fat cells
macrophages
• immune cells that engulf pathogens
mast cells
• release histamine • inflammation response
functions of the integumentary system
• homeostasis • protection • thermoregulation
arrector pili muscle
• tiny smooth muscle attached to hair follicles • when cold - contracts - goosebumps
hypodermis (subcutaneous layer)
• not part of the skin but lies under it • made mostly of adipose tissue • insulation, energy storage , anchors skin to underlying organs
2 types of sweat glands
• eccrine glands • apocrine glands
eccrine glands
• found almost everywhere • open directly to the skin surface • cool the body thru sweat + evaporation • controlled by hypothalamus
apocrine glands
• found in armpits, groin, around nipples • become active at puberty • secrete thicker sweat into hair follicles • play a role in body odor • not for thermoregulation
vasoconstriction
• when you’re cold, dermal arterioles vasoconstrict • blood is kept deep - less heat lost