Cell Signaling Part 2

transmembrane proteins that display their ligand binding domains on the outer surface of the plasma membrane

largest class of enzyme coupled receptors

ligand binding allows —- formation which results in —-

• a small GTP binding protein that is bound by a lipid tail to the cytoplasmic face of the plasma membrane • a monomeric GTPase

virtually all RTK’s actiavte

mediate cell proliferation in wound healing and nerve growth factor receptors

Ras-Gef activates or deactives Ras?

Ras-Gap activates of deactivates Ras?

upon activation of Ras, it will activate what?

MAP kinases change what two things

growth factor signaling

RTK’s activate to promote cell growth and survival

PI3K pathway

rapator

rictor

insulin signaling

54 kDa lipidphosphatase the second most frequently mutated gene in human cancer functions to antagonize PI3K/Akt signaling

cytokine signaling

signaling through interferons and hematopoietic receptors occur through the

inhibitors of the JAK-STAT pathway

family of 8 mobile transcription factors

3 different types of smads

• regulated by phosphorylation - smad 1 2 3 5 8

is not phosphorylated itself smad 4