L-5 Basics of pharmacology

how drugs produce change in patients and the differences in patient responses to medication

its the dose required to produce a specific therapeutic responses in 50% of the group.

-helps predict if drug will produce change -will ensure that drug will provide safe, effective treatment

-determines the dose of the drug that will be lethal (harmful) in 50% of the group -used to assess safety of the drug and for calculating the therapeutic index

-the does that will produce a given toxicity

-its the measure of a drugs safety margin -the higher the value the safer the drug -therapeutic index = median lethal dose/median effective dose

it describes how the therapeutic response to a drug changes as the medication does is increased

phase 1: occurs at lowest dose - few target cells affected by drug phase 2: linear relationship - most desirable range - linear relationship between patient and drug phase 3: plateau reached - increase dose no therapeutic effect but may produce bad effects

relation between the dose of the drug and the therapeutic effect - refers to the drugs strength - therapeutic effect at a lower dose = potent ((you read it horizontally from graph)

ability of drug to produce therapeutic effect (you read it vertically from graph)

a drug that’s capable of binding with a receptor to produce a response can mimic endogenous substances and sometimes produce a greater response

produces a weaker, or less efficacious, response at a receptor than a full agonist.

a drug that binds to a receptor site and blocks endogenous from acting