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enzyme-coupled receptors

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Total cards: 24•Content version: v3•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

what does RTK stand for

Back (Answer)

receptor tyrosine kinase

#2
Front (Question)

what is a receptor tyrosine kinase an example of

Back (Answer)

an enzyme-coupled receptor

#3
Front (Question)

what type of enzymatic activity does a receptor tyrosine kinase have

Back (Answer)

intrinsic

#4
Front (Question)

where in the cell are RTKs located

Back (Answer)

membranes

#5
Front (Question)

what are the two domains of an RTK

Back (Answer)

cytosolic and extracellular

#6
Front (Question)

where does a ligand bind to an RTK

Back (Answer)

extracellular domain

#7
Front (Question)

describe the structure of the RTK that spans the membrane

Back (Answer)

transmembrane alpha helix

#8
Front (Question)

describe the cytosolic domain of an RTK

Back (Answer)

it contains protein tyrosine kinase activity

#9
Front (Question)

list some possible ligands for an RTK

Back (Answer)

growth factors (NGF, FGF, EGF), insulin

#10
Front (Question)

T or F: most RTKs are monomeric

Back (Answer)

true

#11
Front (Question)

how is the intrinsic kinase activity of an RTK activated

Back (Answer)

binding of a ligand = dimerization = activation of kinase activity

#12
Front (Question)

what happens once RTKs dimerize

Back (Answer)

trans-autophosphorylation (each monomer phosphorylates the other)

#13
Front (Question)

what does trans-autophosphorylation do

Back (Answer)

activates kinase domains

#14
Front (Question)

what happens after trans-autophosphorylation

Back (Answer)

conformational change that fully activates kinase activity, then autophosphorylation

#15
Front (Question)

what happens to the RTK after autophosphorylation

Back (Answer)

it generates binding sites for signaling proteins which can now become activation, and now can relay the signal downstream

#16
Front (Question)

what pathway do RTKs activate

Back (Answer)

Ras/MAP pathway

#17
Front (Question)

what is Ras

Back (Answer)

a monomeric G protein

#18
Front (Question)

what is Ras activated by

Back (Answer)

GEF

#19
Front (Question)

where is Ras within the cell

Back (Answer)

anchored to the cytoplasmic side of the PM by a covalently attached lipid

#20
Front (Question)

T or F: Ras interacts directly with the RTK

Back (Answer)

false! there is no direct interaction

#21
Front (Question)

what two proteins serve as linkers between Ras and RTK

Back (Answer)

GRB2 and Sos

#22
Front (Question)

describe the process of indirect activation of Ras by RTK

Back (Answer)

Ras=GDP bound (inactive). GRB2 interacts with active RTK via it’s SH2 domain and with SoS via it’s SH3 domain. This brings Sos to the PM to interact with Ras. Sos=GEF=Ras is GTP bound (active). Ras can now activate a downstream effector (its target)

#23
Front (Question)

what 3 proteins are involved in the MAP kinase module

Back (Answer)

Raf, MEK, Erk

#24
Front (Question)

describe how Ras activates the MAP kinase module

Back (Answer)

Ras activates Raf via direct contact. Raf activates Mek via phosphorylation, Mek activates Erk via phosphorylation. Erk can now phosphorylate different things