Cell Interactions 4
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What are the three types of cell interactions?
Adhesion, Tight, and GAP junctions
What are adhesion junctions ?
Lots of strong cells holding onto eachother tied directly to the cytoskeleton
Why do adhesion junctions have to hold each other tightly ?
So that adhesion junctions wont break easily apart
What are the two categories of cell adhesion molecules ?
Heterophilic and homophilic interactions
Define heterophilic interactions
Two different types of proteins that interact with each other
Define homophilic interactions
Two transmembrane proteins from two different cells that are the same proteins
What are the specific adehseion junctions that we’ll be focusing on ?
Desmosomes and Adheren junctions
What do cadherins do ?
Kink cells together and use transmembrane proteins
What type of interaction would cadherins be classified as ?
Homophilic interaction
What do cadherins interact with ?
The actin cytoskeleton through adaptor proteins
Define Desmosomes
A form of adherin junction, but use different cytoskeleton components
What type of interaction would Desmosomes be classified as ?
Heterophilic
What are both Desmosomes and adherin junctions known as ?
Adhesion junctions
Are tight junctions strong ?
No, they are not
What is the purpose of tight junctions ?
To provide a seal to prevent substances from passing through cells
Is homophilic between or within tissues ?
Within tissues
Is heterophilic between or within tissues ?
Between tissues