Infection - CH. 9
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Commensalism
Colonizing bacteria obtain what they need without host body being affected.
Portals of entry
Parenteral Direct Contact Ingestion Inhalation
Communicability
Ability to spread from one individual to others and cause disease
Infectivity
Ability of pathogen to invade and multiply in host.
Virulence
Degree to which a microorganism is capable of causing infectious disease
Adhesion
Prevents pathogens from being swept from the body
Mechanisms of adhesion
Slime layer Proteins (COVID-19 spike protein) Pili or fimbriae
Biofilm
Community of bacteria that colonize together within a sticky web of extracellular material biofilms Protects from antibiotics and host elimination
First stage of infection
Colonization
Mechanism of action
How microorganism damages tissue
Toxigenicity
Ability to produce soluble toxins or endotoxins, factors that greatly influence the pathogen’s degree of virulence
Endotoxins
LPS contained in the cell walls of gram-negative organisms released during cell destruction that activate the inflammatory response, immune, response, and produce fever (pyrogenic)
Exotoxin
Enzymes released during growth of the bacteria, can damage the plasma membranes of host cells or can inactivate enzymes critical to protein synthesis.
Stages of Infection
Exposure Incubation Prodromal Acute stage (invasion) Convalescent Resolution
Exposure period
Host exposed and infected by infective agent
Incubation period
Begins active replication - asymptomatic
Prodromal stage
Generic symptoms appear and pathogens continue to multiply
Acute Stage (Invasion)
Maximum impact of infectious process
Convalescent Stage
Containment, repair of tissue Immune system successfully removes pathogen and symptoms decline
Resolution stage
Total elimination of pathogen from body
What happens during acute stage?
Proliferation and dissemination of pathogen - invading further w/larger impact Production of toxic byproducts Inflammatory and immune responses triggered SPECIFIC symptoms
Staphylococcus, Streptococcus, TB
Toxins alter function for immune system to fight off or resist immune defenses
Bacterial growth phases
Initial lag phase Log phase Stationary phase Death/spore formation
Spores
Dehydrated structures that represent a formant or nonvegetative state of a bacteria Formed during nutrient deprivation/harsh condition Highly resilient, can survive for centuries Germinate to VEGETATIVE state when water and nutrients are available