proteins III

Fibrinogen • one of the largest protein in the plasma • most abundant in coagulation factors • one of APR , markedly increase during inflammatory process

Fibrinogen - one of the largest protein in the plasma - most abundant in coagulation factors - one of APR , markedly increase during inflammatory process - marker for long tern prognosis of cardio vascular disease -

Fibrinogen • one of the largest protein in the plasma • most abundant in coagulation factors • one of APR , markedly increase during inflammatory process • marker for long tern prognosis of cardio vascular disease • high levels may cause elevated ESR • increase: BIRTH CONTROL, pregnancy , inflammatory disease

complement • one of the natural defense mechanism • it circulates as non functional precursors • C3 is the most abundant form in serum

C reactive protein • is a member of pentraxin protein family • binds to C polysaccharide of the pneumococci • appears in the blood of the patients with DIVERSE INFLAMMATORY DISEASE • used as EARLY WARNING TEST to persons at risk of coronary artery disease

C reactive protein • is a member of pentraxin protein family • binds to C polysaccharide of the pneumococci • appears in the blood of the patients with DIVERSE INFLAMMATORY DISEASE • used as EARLY WARNING TEST to persons at risk of coronary artery disease • RAPID TEST FOR PRE SUMPTIVE DIAGNOSIS OF BACTERIAL VERSUS VIRAL INFECTION

Myoglobin • a small heme protein found in skeletal and cardiac muscle • it is one of the marker to diffuse out of ischemic muscle cells • a marker for CHEST PAIN and EARLY DETECTION of AMI

myoglobin • useful marker for monitoring the SUCCESS OR FAILURE OF REPERFUSION • it is one of the marker to diffuse out of ischemic muscle cells • a marker for CHEST PAIN and EARLY DETECTION of AMI

TnC , TnI, TnT - present in both cardiac and skeletal muscles TnC - binds tocalcium ions that regualted muscle contractions Tni and TnT - cardiac marker that depend on antibodies and calibrators

TROPONIN - they are regulators of ACTIN AND MYOSIN - MOST IMPORTANT MARKER FOR CARDIAC INJURY (AMI) - they are derived from heart muscles - the levels of blood may elevate after AMI attack in the absence of CK-Mb elevations `

troponin T(TnT)/ tropomyosin binding subunit • specific for HEART MUSCLES • VALUABLE TOOL in diagnosis of AMI • assessment of early and late AMI; elevated in Renal disease amd muscular dystrophy • sensitive marker for UNSTABLE ANGINA • Use for monitoring the effectiveness of THROMBOLYTIC THERAPY IN AMI PATIENTS

troponin T(TnT)/ tropomyosin binding subunit • specific for HEART MUSCLES • VALUABLE TOOL in diagnosis of AMI • assessment of early and late AMI; elevated in Renal disease amd muscular dystrophy • sensitive marker for UNSTABLE ANGINA • Use for monitoring the effectiveness of THROMBOLYTIC THERAPY IN AMI PATIENTS

Troponin I (TnI) / inhibitory subunit or actin binding unit • only found in MYOCARDIUM • GREATER CARDIAC SPECIFCITY than TnT • HIGHLY SPECIFIC for AMI - not elevated in renal disease • very sensitive indicator of even minor amount of cardiac necrosis