ANTINEOPLASTICS

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

Front (Question)

1 gram of tumor is equivalent to

Back (Answer)

10^9 or 1 billion cells

Front (Question)

A very common adverse reaction of alkylating agents used in the tx of cancer

Back (Answer)

Alopecia

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS Alkylating agents replace H with an alkyl group, which causes ____.

Back (Answer)

DNA strand breakage

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS Mainstay therapy for solid tumors followed by autologous bone marrow transplantation

Back (Answer)

Thiotepa

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS Dialkylating agent drug of choice for Hodgkin’s disease

Back (Answer)

Mechlorethamine

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS For germ cell testicular cancer

Back (Answer)

Ifosfamide

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS Causes sulfur stripping

Back (Answer)

Busulfan

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS Cell cycle non-specific phosphoramide mustard (major metabolite)

Back (Answer)

Cyclophosphamide

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS For multiple myeloma

Back (Answer)

Melphalan

#10

Front (Question)

ALKYLATING AGENTS: NITROGEN MUSTARDS 1st line agent for chronic lymphocytic leukemia and macroglobulinemia

Back (Answer)

Chlorambucil

#11

Front (Question)

ALKYLATING AGENTS: ORGANOPLATINUM MOA of organoplatinum

Back (Answer)

DNA strands cross-linking

#12

Front (Question)

ALKYLATING AGENTS: ORGANOPLATINUM Most reactive and most effective in platinating DNA

Back (Answer)

Cisplatin

#13

Front (Question)

ALKYLATING AGENTS: ORGANOPLATINUM Carboplatin is administered with ____ to reduce toxicity

Back (Answer)

1,1-cyclobutane-dicarboxylate

#14

Front (Question)

ALKYLATING AGENTS: ORGANOPLATINUM ____ is administered with 1,1-cyclobutane-dicarboxylate to reduce toxicity

Back (Answer)

Carboplatin

#15

Front (Question)

ALKYLATING AGENTS: ORGANOPLATINUM Activated in low chloride environment, not recognized by MMR

Back (Answer)

Oxaliplatin

#16

Front (Question)

ALKYLATING AGENTS Alkylates DNA with restricted uncoiling and replication of strands

Back (Answer)

Nitrosoureas

#17

Front (Question)

ALKYLATING AGENTS: NITROSOUREAS 1st line agent for metastatic brain tumor

Back (Answer)

Lomustine

#18

Front (Question)

ALKYLATING AGENTS: NITROSOUREAS 2nd line agent for Hodgkin’s disease

Back (Answer)

Lomustine

#19

Front (Question)

ALKYLATING AGENTS: NITROSOUREAS For brain tumors and can penetrate BBB

Back (Answer)

Carmustine

#20

Front (Question)

ALKYLATING AGENTS: OTHERS 3 agents for Hodgkin’s lymphoma

Back (Answer)

• Mechlorethamine • Lomustine • Procarbazine

#21

Front (Question)

ALKYLATING AGENTS: OTHERS 2 agents that form DNA adducts

Back (Answer)

• Dacarbazine • Temozolomide

#22

Front (Question)

ALKYLATING AGENTS: OTHERS Involved in hydroxylation of methyl group

Back (Answer)

Altretamine

#23

Front (Question)

ALKYLATING AGENTS: OTHERS 2nd line agent for ovarian cancer

Back (Answer)

Altretamine

#24

Front (Question)

ALKYLATING AGENTS: OTHERS Induces hyperglycemia on animal model

Back (Answer)

Streptozocin