ANTIVIRALS
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4 Common Problems on Antivirals
• Resistance • Ineffective (non-replicating virus) • Limited spectrum • -Static RILS
Enumerate the viral process.
• Attachment • Entry • Release • Replication • Assembly • Release AERRAR
CHEMOPROPHYLAXIS INFLUENZA For influenza A + Parkinson’s disease
Amantadine (Symmetrel)
CHEMOPROPHYLAXIS INFLUENZA Adverse effect of Amantadine (Symmetrel)
Livedo Reticularis Others: CNS anticholinergic effects - Anxiety, Insomnia, Seizures
CHEMOPROPHYLAXIS INFLUENZA MOA of amantadine
• Viral uncoating inhibition • Viral assembly (Hemagglutinin processing)
CHEMOPROPHYLAXIS INFLUENZA Tricyclic amine compounds
Amantadine + Rimantadine
CHEMOPROPHYLAXIS INFLUENZA For influenza A at low concentrations
Amantadine + Rimantadine
CHEMOPROPHYLAXIS INFLUENZA Methylated amantadine but 4-10 times more active and cause GI problems
Rimantadine
CHEMOPROPHYLAXIS INFLUENZA Rimantadine causes ____ problems, while amantadine causes ____ effects.
• GI • Anti-cholinergic
NEURAMINIDASE INHIBITORS Neuraminidase inhibitors are active against ____.
Influenza A and B
NEURAMINIDASE INHIBITORS Adverse effect of oseltamivir
Nausea & Vomiting
NEURAMINIDASE INHIBITORS Adverse effect of zanamivir
Bronchospasms C/I: COPD and Asthma
NEURAMINIDASE INHIBITORS Neuraminidase inhibitors are ____ analogues.
Sialic acid
NEURAMINIDASE INHIBITORS MOA of oseltamivir and zanamivir
Prevents the release and spread of new virions
NUCLEOSIDE ANALOGUES Trifluridine Identify the base.
Thymine
NUCLEOSIDE ANALOGUES Idoxuridine Identify the base.
Thymine
NUCLEOSIDE ANALOGUES MOA of nucleoside analogs
Inhibiting viral replication Act as antimetabolite
NUCLEOSIDE ANALOGUES Vidarabine Identify the base.
Adenosine
NUCLEOSIDE ANALOGUES Acyclovir Identify the base.
Guanosine
NUCLEOSIDE ANALOGUES Valacyclovir Identify the base.
Guanosine
NUCLEOSIDE ANALOGUES Famciclovir Identify the base.
Guanosine
NUCLEOSIDE ANALOGUES Penciclovir Identify the base.
Guanosine
NUCLEOSIDE ANALOGUES Ganciclovir Identify the base.
Guanosine
NUCLEOSIDE ANALOGUES Cidofovir Identify the base.
Cytosine