Introduction To Toxicology
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Is the ability of the substance to produce injury upon reaching a susceptible site in/on the body
Toxicity
It is the science of poisons including not only their chemical and physical effects but for their detection and antidotes.
Toxicicology
Scientist who study this harmful effect and asses the probability of their occurrence are called ________
Toxicologist
What are the 4 major Disciplines in Toxicology
Mechanistic , Descriptive , Clinical and Forensic
One of the Discpline in Toxicology that uses results from animal experiments to predict the level of exposure to harmful to humans
Descriptive
Descriptive Discipline is also known as _________
Risk Assestment
Refers to toxic substances that are produced naturally
Toxins
Provides basis of therapy design and develop test for assestment
Mechanistic
One of the Discpline in Toxicology that study the interelationship between toxin exposure and disease state
Clinical Discpline
One of the Discpline in Toxicology concerned with medicolegal consequence of toxin exposure
Forensic
What are the 5 Sub-Discipline of Toxicology
Economic toxicology, Forensic Toxicology , Clinical toxicology , Environmental Toxicology, Industrial Toxicology.
Refers to toxic substances that are produce by or are a by product of human made activities
Toxicant
One of the Sub-Discpline in Toxicology that concerned in chemicals used in drugs, Food Additives , pesticides and cosmetics
Economic Toxicology
One of the Sub-Discpline in Toxicology that helps establish cause and effect relationships between exposure to a drug or chemical and the toxic and lethal effect result
Forensic Toxicology
Is use to describe the nature of adverse effect produced and the condition neccessary for their production
Toxicity
One of the Sub-Discpline in Toxicology that evaluate the synergestic effects of chemicals that are contaminant of food , water , soil or the air
Environmental Toxicology
One of the Sub-Discpline in Toxicology that evaluate the effects of pollutant in the working environment .
Industrial (Occupational) Toxicology
General Fxn of Toxicology
G-I-Q-I-C-D-P-G-M
Wrote the famous Treatise on Poison and their antidote
Moses Maimonides (1335-1204)
Paracelcus is Famous for his word that
The Dose Makes the Poison All Substance are Poison There is None which is not poison The right dose differentiate poison from remedy
Noted as the Father of Pharmacology
Francoise Magendie (1783-1855)
French Toxicologist and Chemist, The founder of Science of Toxicology
Mathieu Joseph Bonaventure
Synthesized caffeine and recieved the nobel prize in chemistry in 1902
Emil Fischer 1852-1919
4 Basis of Classifying Poisons
Base on Its Analysis Base on the organ or system considered the target site of the effect of the chemical Mechanism of Toxicity Manner of Exposure