Drugs

> Very effective anti-emetic • Use in acute gastroenteritis, cytotoxic induced vomiting, motion sickness [higher dose] • effective against central and peripheral causes of emesis as works on last step of vomiting reflex in CNS • NK1 Receptor antagonist in Nucleus Tractus Solitarius

• Antiemetic • D2 and 5HT3 antagonist [CRTZ and periphery], and peripheral procholinergic effects • use in central/peripherally induced vomiting, chemotherapy, gastroesophageal reflux, decreased gastric emptying cases • more potent in dogs dueto D2 activity

• Amtiemetic • a1 and a2 Ant, D2 Ant, H1 and H2 Ant, Muscarinic Cholinergic Ant • acts on CRTZ, vomiting centre, vestibular system and periphery > not vet registered so few indications

Anthistamines: Antiemetic • act on CRTZ in motion sickness in the DOG only • off label use in UK

Anthistamines: • H1 and H2 in CRTZ • Antiallergy

• 5HT3 antagonist (CRTZ and periphery) • usually for cytotoxic drug induced emesis • much more effective antiemetic than metoclopramide • expensive

• 5HT3 antagonist (CRTZ and periphery) • usually for cytotoxic drug induced emesis • much more effective antiemetic than metoclopramide • expensive

Anticholinergic -Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

Anticholinergic -Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

Anticholinergic -Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

Anticholinergic -Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

Anti-ulcer • inexpensive • oral administration different in V+ patient • frequent administration ~4hrs = low owner compliance • treat but DO NOT PREVENT

• H2 R antagonists • Anti-ulcer • effective for gastric ulceration caused by NSAIDs and uraemia (amongst others) • vet registered • differ to other H2 R ants in potency, but = effective

Anti-ulcer

Anti-ulcer • Synthetic PGE2 • Management/prevention of NSAID tox • Causes abortion in humans (morning after pill)

Anti-ulcer

• H2 R antagonists • Anti-ulcer • effective for gastric ulceration caused by NSAIDs and uraemia (amongst others) • differ to other H2 R ants in potency, but = effective • prokinetic

• H2 R antagonists • Anti-ulcer • effective for gastric ulceration caused by NSAIDs and uraemia (amongst others) • differ to other H2 R ants in potency, but = effective

• NOT morphine! • D2 Ag • Potent emetic in the dog

• A2 Ag • Sedative • Potent emetic in cats

• A2 blocker - Potent antiemetic in cats

• Absorbant/prtectant for diarrhoea?

• Absorbant/protectant for diarrhoea - Avoid in cats

NSAID analgesic and antipyrexic