Synthetic routes- reactions and conditions
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dihalogenoalkane to diol
• Aqeous KOH • heat under reflux • nucleophilic substitution
alkene to dihalogenoalkane
• X2 • room temp • electrophilic addition
alkene to polyalkene
• high pressure • catalyst
alkane to halogenoalkane
• X2 • U.V light • free radical substitution
alkene to halogenoalkane
• HBr or HCl • room temp • electrophilic addition
halogenoalkane to alkene
• ethanolic KOH • heat under reflux • elimination
halogenoalkane to alcohol
• aqeous KOH • heat under reflux • nucleophilic substitution
alkene to alcohol
• Step 1: conc sulfuric acid, electrophilic addition • Step 2: H2O warm, hydrolysis
alcohol to alkene
• concentrated sulfuric acid or concentrated phoisphoric acid • 180° • elimination/dehydration
halogenoalkane to primary amine
• Alcoholic (ethanolic) ammonia • heat under pressure • nucleophilic subsitution
halogenoalkane to nitrile
• KCN in ethanol/water • heat under reflux • nucleophilic substitution
nitrile to primary amine
• LiAlH4 in ether (or H2 and nickel) • reduction
primary amine to secondary/tertiary amine
• halogenoalkane • nucleophilic substitution
primary amine to secondary amide/N-substituted amide
• acyl chloride • room temp • nucleophilic addition-elimination
alcohol to ester
• carboxylic acid & H2SO4 • heat • esterification
ketone to alcohol
• NaBH4 • reduction • nucleophilic addition
secondary alcohol to ketone
• H+/Na2Cr2O7 • heat • oxidation
primary alchohol to aldehyde
• H+/Na2Cr2O7 • heat and distill • partial oxidation
aldehyde to alcohol
• NaBH4 • reduction • nucleophilic addition
ketone to hydroxynitrile
• NaCN and sulfuric acid • Nucleophilic addition
aldehyde to hydroxynitrile
• NaCN and sulphuric acid • nucleophilic addition
aldehyde to carboxylic acid
• H+/k2Cr2O7 • heat under reflux • excess oxidising agent oxidation
primary alcohol to carboxylic acid
• H+/k2Cr2O7 • heat under reflux • excess oxidising agent oxidation
carboxylic acid to ester
• Alchohol and conc sulphuric acid • heat • esterification