cell mediated (specific) response
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what cells are involved in the cell mediated response?
T cells
briefly describe what happens in the cell mediated response
• receptors on T cells bind to antigens on antigen presenting cells • T cells divide rapidly by mitosis (clonal expansion)
state 4 examples of antigen presenting cells
• infected body cells with viral antigens • macrophages which have engulfed and destroyed a pathogen • transplanted organ cells • cancer cells with abnormal shaped antigens
stage 1 (APC)
after being engulfed and destroyed in phagocytosis, the cell is antigen presenting
stage 2 (receptors)
T helper cells receptors attach to antigens of APCs
stage 3 (interleukins)
interleukins are produced, activating T helper cells to rapidly divide by mitosis - clonal expansion
stage 4 (differentiation)
cloned T helper cells differentiate - T memory cells - T killer cells - T regulator cells
what are T regulator cells?
suppress immune response so that cell mediated response only occurs when pathogens are detected
state 2 examples of T helper differentiation in terms of interleukins
• produce interleukins to activate B lymphocytes • produce interleukins to stimulate macrophages
describe T killer cells
• destroy abnormal/infected cells • release perforin which embeds in pathogen cell membrane and creates a pore; allows substances to exit and enter, causing cell death • common in viral replication • body cells are sacrificed to prevent viral replication