Translational Science
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Why do PARP inhibitors selectively kill BRCA-deficient tumor cells?
Because BRCA-deficient cells cannot repair double-strand breaks that accumulate when PARP-mediated repair is blocked, leading to lethal genomic instability.
How can tumors develop resistance to PARP inhibitors?
By acquiring secondary mutations that restore BRCA function or compensate for homologous recombination defects.
Why can a single tumor biopsy give an incomplete picture of cancer genetics?
Because tumors are heterogeneous and evolve over time, meaning different regions or later stages of the tumor may contain different mutations.
Why do BRCA mutations increase cancer risk?
Because BRCA proteins are required for homologous recombination, and their loss causes genomic instability.
Explain pro-apoptotic therapy
Pro-apoptotic therapy is a treatment strategy that induces cancer cell death by activating or restoring apoptotic pathways