Gastric, Intestinal, and Pancreatic Function (PART 3)
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Most common cause of chronic pancreatitis
Alcoholism
Two indirect tests used to diagnose this condition
Measure fecal chymotrypsin and fecal elastase-1
Specific diagnostic usefulness of the measurement of elastase-1
Secreted in any inflammatory state; sensitive and specific marker of chronic pancreatitis
Specific diagnostic usefulness of the measurement of trypsin
Highly sensitive indicator of pancreatic disease; recommended as screening test for CF in 5-day-old infants
conditions which may lead to the malabsorption syndrome
*Pancreatic insufficiency - celiac disease - resection of ilium - parasitic infection of the gut (others on slide 159)
Why do patients with malabsorption syndrome have steatorrhea, weight loss, vit deficiencies, anemia, edema, coag disorders and osteomalcia
Deficiencies of fat and water soluble vitamins
Four tests used to evaluate the malabsorption syndrome
• Carotene • Microscopic examination of stool for fat • D-xylose absorption test • Breath hydrogen test
Principle and specific area of the GI tract assessed via the D-xylose absorption test
Assesses the functional integrity of the small intestine
List the specific diagnostic usefulness of the breath hydrogen test
Assesses whether malabsoption is caused by bacterial overgrowth or a lactase deficiency
Describe the multiple endocrine neoplasia (MEN) syndrome
Occurrence of tumors involving two or more endocrine glands within a single patient - Two types: MEN 1 (Wermer’s Syndrome); MEN 2 (Sipple’s Syndrome)