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Diffusion and partition

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卡片总数: 6内容版本: v4公开卡包更新时间: 8/1/2026

卡片预览 (6 张)

#1
正面 (问题)

what is partition?

背面 (解答)

‘diffusion of drug between two immiscible phases’

#2
正面 (问题)

equation of partition coefficient?

背面 (解答)

P= Co /Cw

#3
正面 (问题)

what does the partition coefficient mostly apply to?

背面 (解答)

drug mostly in its lipophilic form unionised species

#4
正面 (问题)

what is the apparent partition coefficient for solute ionisation in water?

背面 (解答)

Papp= [HA]o / ([HA]w + [A-])

#5
正面 (问题)

what equation is used for weak acids?

背面 (解答)

Log [P/D – 1] = pH - pKa

#6
正面 (问题)

what equation is used for weak bases?

背面 (解答)

Log [P/D – 1] = pKa - pH