Endocrinology Part 1 (Hypothalamus, Pituitary, and Pineal Gland)
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Controls flow of information between cells and tissues by releasing hormones
ENDOCRINE SYSTEM
Substances secreted by endocrine gland that conveys information to its target cells
HORMONES
All hormones will act on all cells
F (Not ALL hormones will act on all cells; requires appropriate cell receptor)
Chemical signals produced by specialized cells secreted into the bloodstream and carried to a target tissue (with specific receptor)
Hormones
Generally, act at sites distant from their place of origin Ex: some pituitary hormone acts on thyroid gland, gonads, adrenal gland
Hormones
Regulates cells and organs to maintain homeostasis Ex: ADH – regulates water homeostasis Aldosterone – regulates Na homeostasis
Hormones
hormone concentrations are regulated by?
feedback mechanisms/loop
Actions of hormones
1) Regulatory substance 2) Controls body functions
TYPES OF HORMONE ACTION
ENDOCRINE PARACRINE AUTOCRINE JUXTACRINE INTRACRINE
Acts at a distant site from their place of origin
endocrine
Acts on the neighboring cells
paracrine
Acts on its self Ex: hormone produced by hypothalamus will act on hypothalamus
autocrine
Remain intact/bound to cell membrane; acts on adjacent cells by cell-to-cell contact with cell receptors
Juxtacrine
how does juxtacrine acts on adjacent cells
cell-to-cell contact
Acts inside the cells (non-producible/released)
intracrine
CHEMICAL COMPOSITION/NATURE OF HORMONES
PEPTIDES & PROTEINS STEROID AMINO ACID DERIVATIVES (Amines) FATTY ACID DERIVATIVES
chemical composition of water soluble hormones
PEPTIDES & PROTEINS
chemical composition of hormones that do not require carrier (transport proteins)
PEPTIDES & PROTEINS
Nature of majority of the hormones
PEPTIDES & PROTEINS
chemical composition of hormones that is synthesized and stored within cells
PEPTIDES & PROTEINS
chemical composition of hormones that is stored inside the cell where they are produced
PEPTIDES & PROTEINS
Example of hormone with peptide & protein nature
GH – produced by pituitary gland; cells that produce GH will synthesize GH but they are retained inside the cell; only released when the body needs GH
Steroid hormones regulates?
sexual dev’t and characteristics
Precursor of steroid hormones
cholesterol (a sterol)