Hormone Synthesis, Secretion and Transport
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3 types of coat proteins
Cop 1, Cop II and clathrin
Functions of each coat protein
• COP II mediates transfer of vesicles from the rough ER to the cis-Golgi/cis-Golgi network • COP I mediates retrograde transport from the trans- to the medial – to the cis-Golgi as well as from the cis-Golgi/cis-Golgi network to the rough ER • Clathrin mediates transfer of vesicles that bud from the trans-Golgi network and the plasma membrane and that then fuse with late endosomes
Vesicular secretion (steps 1-6)
• Sorting hormone for secretion • Coat protein association (e.g. COP I retrograde or COP II forward) and vesicle formation • Budding and trafficking (v-SNARE/t-SNARE) not random – uses directed receptor recognition • Uncoating • Docking • Fusion to target membrane
vesicular secretion is driven by what?
GTP hydrolysis
what influences the half-life of mRNA
5” cap and length of 3’ poly A tail
are steroids and eicosandoids secreted immediately or inependently
secreted immediately so control at synthesis level - plasma membrane soluble so can easily pass through
are peptide hormones secreted immediately or independantly
• synthesis and secretion regulated independently